ROBIN TUTT VOLLMER, MD
Medical Practice at Trent Dr, Durham, NC

6662114, Dec 9, 2003

Aug 21, 2000

09/642905

Robert H. Christenson - Joppa MD
Show-Hong Duh - Ellicott City MD
Robin T. Vollmer - Durham NC
E. Magnus Ohman - Durham NC
Trevor D. Thompson - Lilburn GA
L. Kristin Newby - Durham NC
Robert M. Califf - Durham NC

Duke University - Durham NC
University of Maryland - Baltimore MD

G01N 3348

702 19, 435 4, 435 15, 703 11

A method for predicting the clinical outcome for a patient after the patient has received therapy for an acute coronary syndrome such as myocardial infarction comprises: (a) optionally, but preferably, detecting a first variable comprising a serum creatine kinase-MB release curve area in the patient after initiation of said therapy; (b) detecting a second variable comprising a serum creatine kinase-MB release curve maxima in the patient after initiation of said therapy; then (c) optionally, but preferably, detecting a third variable comprising the slope of the descending portion of the serum creatine kinase-MB release curve after initiation of said therapy (wherein a steep slope for said descending portion is a more favorable indicator of clinical outcome than a shallow slope); and (d) generating a prediction of clinical outcome for said patient from the variables collected above. The method is useful in conjunction with established therapies such as thrombolytic therapy, and is particularly useful as a surrogate end point in clinical trials of new potential therapies.