Inventors:
Mary L. Houchin - Rockville MD, US
Robin H. Lee - San Diego CA, US
Hong Qi - San Diego CA, US
Greg Oehrtman - San Diego CA, US
Robert N. Jennings - San Diego CA, US
Scott H. Coleman - San Diego CA, US
International Classification:
A61K 9/00, A61K 38/00, A61K 38/22, A61K 38/28, A61K 38/38, A61K 31/60, A61K 31/135, A61P 3/10, A61P 3/08, A61P 3/00, A61P 3/04, A61P 3/06
US Classification:
424400, 514 48, 514 58, 514 59, 514 69, 514 74, 514159, 514649
Abstract:
The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like. The formulations offer distinct advantages of long shelf life for the stability and potency of the formulation and sustained release of active pharmaceutical ingredients to reduce the frequency of medication dosing and to increase patient compliance.