ROBERT Y ZHAO
Broker in Lexington, MA
License number
Massachusetts 9050319
Issued Date
Oct 31, 2002
Expiration Date
Dec 6, 2012
Type
Salesperson
Address
Address
Lexington, MA 02421
Professional information
Novel Benzodiazepine Derivatives
US Patent:
2013030, Nov 14, 2013
Filed:
Mar 14, 2013
Appl. No.:
13/826181
Inventors:
Wei Li - Acton MA, US
Nathan Elliott Fishkin - Weymouth MA, US
Robert Yongxin Zhao - Lexington MA, US
Michael Louis Miller - Framingham MA, US
Ravi V.J. Chari - Newton MA, US
Nathan Elliott Fishkin - Weymouth MA, US
Robert Yongxin Zhao - Lexington MA, US
Michael Louis Miller - Framingham MA, US
Ravi V.J. Chari - Newton MA, US
International Classification:
C07D 487/04, C07K 16/28, A61K 45/06, A61K 38/07, C07K 5/103, A61K 47/48, A61K 31/5517
US Classification:
4241781, 5303917, 514219, 540494, 514 219, 530330, 514 37, 514 167, 514 177, 514 154, 514 192, 514 193, 514 194, 514 195
Abstract:
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
Prodrugs Of Cc-A1065 Analogs
US Patent:
8012978, Sep 6, 2011
Filed:
Sep 4, 2008
Appl. No.:
12/204082
Inventors:
Robert Zhao - Lexington MA, US
Ravi V. J. Chari - Newton MA, US
Ravi V. J. Chari - Newton MA, US
Assignee:
ImmunoGen, Inc. - Waltham MA
International Classification:
A61K 31/497, C07F 9/02
US Classification:
5142522, 514411, 548414, 548427
Abstract:
The present invention provides prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group containing a sulfonic acid containing phenyl carbamate, in which the protecting group confers enhanced water solubility upon the prodrug, and in which the prodrug also has a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody, and for the therapeutic use of such prodrug and conjugates, and for processes for preparing such prodrugs and conjugates.
Prodrugs Of Cc-1065 Analogs
US Patent:
2011028, Nov 17, 2011
Filed:
Jul 15, 2011
Appl. No.:
13/184255
Inventors:
Robert ZHAO - Lexington MA, US
Ravi V. J. CHARI - Newton MA, US
Ravi V. J. CHARI - Newton MA, US
Assignee:
IMMUNOGEN, INC. - Waltham MA
International Classification:
A61K 39/395, C07K 16/00, A61P 35/00, C07D 209/56
US Classification:
4241781, 548427, 5303917
Abstract:
The present invention provides prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group containing a sulfonic acid containing phenyl carbamate, in which the protecting group confers enhanced water solubility upon the prodrug, and in which the prodrug also has a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody, and for the therapeutic use of such prodrug and conjugates, and for processes for preparing such prodrugs and conjugates.
Novel Benzodiazepine Derivatives
US Patent:
2013026, Oct 10, 2013
Filed:
Feb 22, 2013
Appl. No.:
13/774059
Inventors:
Wei Li - Acton MA, US
Nathan Elliott Fishkin - Weymouth MA, US
Robert Yongxin Zhao - Lexington MA, US
Michael Louis Miller - Framingham MA, US
Ravi V.J. Chari - Newton MA, US
Nathan Elliott Fishkin - Weymouth MA, US
Robert Yongxin Zhao - Lexington MA, US
Michael Louis Miller - Framingham MA, US
Ravi V.J. Chari - Newton MA, US
International Classification:
A61K 47/48, A61K 45/06
US Classification:
4241811, 5303919
Abstract:
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
Benzodiazepine Derivatives
US Patent:
8426402, Apr 23, 2013
Filed:
Feb 4, 2010
Appl. No.:
12/700131
Inventors:
Wei Li - Acton MA, US
Nathan Fishkin - Weymouth MA, US
Robert Zhao - Lexington MA, US
Michael Miller - Framingham MA, US
Ravi Chari - Newton MA, US
Nathan Fishkin - Weymouth MA, US
Robert Zhao - Lexington MA, US
Michael Miller - Framingham MA, US
Ravi Chari - Newton MA, US
Assignee:
ImmunoGen, Inc. - Waltham MA
International Classification:
C07D 519/00, A61K 31/5517, A61K 31/55, A61P 35/00
US Classification:
514219, 540494
Abstract:
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
Cross-Linkers And Their Uses
US Patent:
8613930, Dec 24, 2013
Filed:
Jul 5, 2012
Appl. No.:
13/542126
Inventors:
Ravi V. J. Chari - Newton MA, US
Robert Yongxin Zhao - Lexington MA, US
Yelena Kovtun - Stow MA, US
Rajeeva Singh - Framingham MA, US
Wayne Charles Widdison - Belmont MA, US
Robert Yongxin Zhao - Lexington MA, US
Yelena Kovtun - Stow MA, US
Rajeeva Singh - Framingham MA, US
Wayne Charles Widdison - Belmont MA, US
Assignee:
ImmunoGen, Inc. - Waltham MA
International Classification:
A61K 39/00, A61K 36/04, C07K 16/06
US Classification:
4241811, 530331, 5303919, 530330
Abstract:
Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.
Methods For The Preparation Of Charged Crosslinkers
US Patent:
8598362, Dec 3, 2013
Filed:
Dec 8, 2011
Appl. No.:
13/315005
Inventors:
Wei Li - Acton MA, US
Robert Yongxin Zhao - Lexington MA, US
Robert Yongxin Zhao - Lexington MA, US
Assignee:
ImmunoGen, Inc. - Waltham MA
International Classification:
C07D 401/00
US Classification:
5462781
Abstract:
Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert the resulting products to substantially a single salt form.
Cross-Linkers And Their Uses
US Patent:
8236319, Aug 7, 2012
Filed:
Apr 30, 2009
Appl. No.:
12/433604
Inventors:
Ravi V. J. Chari - Newton MA, US
Robert Yongxin Zhao - Lexington MA, US
Yelena Kovtun - Stow MA, US
Rajeeva Singh - Framingham MA, US
Wayne Charles Widdison - Belmont MA, US
Robert Yongxin Zhao - Lexington MA, US
Yelena Kovtun - Stow MA, US
Rajeeva Singh - Framingham MA, US
Wayne Charles Widdison - Belmont MA, US
Assignee:
ImmunoGen, Inc. - Waltham MA
International Classification:
A61K 39/00, A61K 38/04, A61K 38/06, C07K 16/08
US Classification:
4241811, 530331, 5303919, 530330
Abstract:
Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.
Cytotoxic Agents Comprising New Tomaymycin Derivatives
US Patent:
8163736, Apr 24, 2012
Filed:
Jul 16, 2008
Appl. No.:
12/174195
Inventors:
Laurence Gauzy - Paris, FR
Herve Bouchard - Thiais, FR
Ravi V. J. Chari - Newton MA, US
Alain Commercon - Vitry-sur-Seine, FR
Robert Zhao - Lexington MA, US
Yonghong Deng - Arlington MA, US
Wei Li - Winchester MA, US
Herve Bouchard - Thiais, FR
Ravi V. J. Chari - Newton MA, US
Alain Commercon - Vitry-sur-Seine, FR
Robert Zhao - Lexington MA, US
Yonghong Deng - Arlington MA, US
Wei Li - Winchester MA, US
Assignee:
sanofi-aventis - Paris
International Classification:
C07D 519/00, C07D 487/00, A61K 31/5517
US Classification:
514220, 540496
Abstract:
The present invention is related to new tomaymycin derivatives, their process of preparation and their therapeutic uses.