ROBERT WILLIAM VAN HOLTEN
Pilots in Flemington, NJ
License number
New Jersey A1954508
Issued Date
Dec 2016
Expiration Date
Dec 2018
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
PO Box 1037, Flemington, NJ 08822
Professional information
Capture, Concentration And Quantitation Of Abnormal Prion Protein From Biological Fluids Using Depth Filtration
US Patent:
7201901, Apr 10, 2007
Filed:
May 23, 2003
Appl. No.:
10/444606
Inventors:
Robert W. Van Holten - Flemington NJ, US
Stephen M. Autenrieth - Bernardsville NJ, US
Stephen M. Autenrieth - Bernardsville NJ, US
Assignee:
Ortho-Clinical Diagnostics, Inc. - Raritan NJ
International Classification:
A61K 39/00, A23L 1/28, A23J 1/00
US Classification:
4241401, 426425, 530419
Abstract:
Methods for producing biological solutions such as immunoglobulins and in particular anti-D immunoglobulin substantially free of abnormal prion protein resulting therefrom. Specifically provided are methods for aggregation of prions and depth filtration of the biological solution to capture and remove abnormal and if desired, normal prion protein. The prion protein may then be eluted from the depth filter and filter washes and concentrated sufficient for detection at limits currently required by available assays.
Optimal Placement Of A Robust Solvent/Detergent Process Post Viral Ultrafiltration Of An Immune Gamma Globulin
US Patent:
2010012, May 27, 2010
Filed:
Jan 25, 2010
Appl. No.:
12/693335
Inventors:
Robert W. Van Holten - Flemington NJ, US
Stephen M. Autenrieth - Bernardsville NJ, US
Stephen M. Autenrieth - Bernardsville NJ, US
International Classification:
C12N 7/06
US Classification:
435238
Abstract:
The solvent-detergent (S/D) process is used to inactivate enveloped viruses in plasma products. While concentrations of 1.0% detergent and 0.3% tri-n-butyl phosphate solvent have been considered necessary for robust removal of viral activity, we show the effectiveness of solvent-detergent treatment after fractionation and nanofiltration of an immune gamma globulin preparation, which required significantly reduced concentrations of solvent and detergent. Reduced levels of solvent and detergent lead to greater efficiencies in their removal post-inactivation with the potential for greater yields and decreased processing costs.
Reinforced Absorbable Synthetic Matrix For Hemostatic Applications
US Patent:
8273369, Sep 25, 2012
Filed:
May 17, 2010
Appl. No.:
12/781103
Inventors:
Dhanuraj S. Shetty - Jersey City NJ, US
Robert W. Van Holten - Flemington NJ, US
Degang Zhong - Branchburg NJ, US
Robert W. Van Holten - Flemington NJ, US
Degang Zhong - Branchburg NJ, US
Assignee:
Ethicon, Inc. - Somerville NJ
International Classification:
A61F 2/00, A61F 13/00, A61L 15/16, A61K 38/00, A61K 38/36, A61K 47/30
US Classification:
424444, 424426, 424447, 514 135, 514 136, 514 137, 514 138, 514 147, 5147723, 602 45, 602 50, 606908
Abstract:
The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.
Surgical Barriers Having Adhesion Inhibiting Properties
US Patent:
8629314, Jan 14, 2014
Filed:
Dec 18, 2008
Appl. No.:
12/338349
Inventors:
Robert W. Van Holten - Flemington NJ, US
Jagdishchandra C. Patel - Lawrenceville NJ, US
Jagdishchandra C. Patel - Lawrenceville NJ, US
Assignee:
Ethicon, Inc. - Somerville NJ
International Classification:
A61F 13/00, A61F 13/51, B32B 23/08, B32B 23/12
US Classification:
602 48, 602 52, 606215, 523105, 428536
Abstract:
An adhesion inhibiting surgical barrier. The surgical barrier includes a wound-facing polymeric coating comprising an enteric polymer; and at least one flexible substrate, the at least one flexible substrate having at least one exterior surface, wherein the polymeric coating is applied to the at least one flexible substrate to substantially cover the at least one exterior surface thereof. A method of inhibiting the formation of adhesions in a patient who has undergone a surgical procedure and a method of repairing a gastric or duodenal perforation are also described herein.
Medically Acceptable Formulation Of A Diisocyanate Terminated Macromer For Use As An Internal Adhesive Or Sealant
US Patent:
8324292, Dec 4, 2012
Filed:
Feb 29, 2008
Appl. No.:
12/040211
Inventors:
Robert B. Vetrecin - Stewartsville NJ, US
Elizabeth Vailhe - Hillsborough NJ, US
Robert W. Van Holten - Flemington NJ, US
Elizabeth Vailhe - Hillsborough NJ, US
Robert W. Van Holten - Flemington NJ, US
Assignee:
Ethicon, Inc. - Somerville NJ
International Classification:
A61L 24/04, A61F 2/00, C08G 18/70, C08G 18/72, C08G 18/77, C07C 265/12
US Classification:
523118, 523111, 523113, 424423, 528 44, 528 59, 528 67, 560330
Abstract:
A medically acceptable formulation comprising a diisocyanate terminated macromer or mixture thereof, and an oxidized cellulose.
Reinforced Absorbable Multi-Layered Fabric For Hemostatic Applications
US Patent:
8329211, Dec 11, 2012
Filed:
May 17, 2010
Appl. No.:
12/781235
Inventors:
Dhanuraj S. Shetty - Jersey City NJ, US
Robert W. Van Holten - Flemington NJ, US
Degang Zhong - Branchburg NJ, US
Robert W. Van Holten - Flemington NJ, US
Degang Zhong - Branchburg NJ, US
Assignee:
Ethicon, Inc. - Somerville NJ
International Classification:
A61F 2/00, A61F 13/00, A61L 15/16, A61K 38/00, A61K 38/36, A61K 47/30
US Classification:
424444, 424426, 424443, 424447, 428215, 428218, 514 135, 514 136, 514 137, 514 138, 514 147, 514772, 602 45, 602 60, 606908
Abstract:
The present invention is directed to a synthetic fabric comprising a multi-layered nonwoven fabric made from staples of a polyglycolide/polylactide copolymer, each layer having a different density. The multi-layer fabric can be used as a reinforced absorbable hemostat medical device.
Hemostatic Medical Device
US Patent:
2008027, Nov 6, 2008
Filed:
May 3, 2007
Appl. No.:
11/743943
Inventors:
Stephen C. Yeadon - Hampton NJ, US
Robert W. Van Holten - Flemington NJ, US
Robert W. Van Holten - Flemington NJ, US
International Classification:
A61M 37/00
US Classification:
604 82
Abstract:
A hemostatic medical device comprising a tubular syringe body extending along an axis and having a front end and a rear end; a plunger axially slidable in the body; a stem projecting axially rearward out of the body from the plunger; a free piston slidable in the body forward of the plunger and subdividing the body forward of the plunger into a front compartment at the front body end and a rear compartment between the plunger and the piston; the syringe body being formed with a mechanism to allow the contents in the rear and front compartments to mix; sterile saline in the rear compartment; and a hemostatic substance in the front compartment.
Viral Clearance Process
US Patent:
6096872, Aug 1, 2000
Filed:
Oct 14, 1997
Appl. No.:
8/950157
Inventors:
Robert William Van Holten - Flemington NJ
Gilbert J. Quinton - Belle Meade NJ
George E. Oulundsen - Nashua NH
Gilbert J. Quinton - Belle Meade NJ
George E. Oulundsen - Nashua NH
Assignee:
Ortho Diagnostic Systems, Inc. - Raritan NJ
Millipore Corporation - Bedford MA
Millipore Corporation - Bedford MA
International Classification:
A61K 39395, C07K 1634
US Classification:
5303901
Abstract:
Methods for producing immunoglobulins and in particular anti-D immunoglobulin substantially free of virus and product resulting therefrom. Specifically provided are methods for nanofiltration of the anti-D immunoglobulin in high ionic strength buffer and with excipient such as polysorbate 80. Additional steps include diafiltration to concentrate the anti-D protein and reduce the concentration of excipient present.
Hemostatic Device
US Patent:
8299316, Oct 30, 2012
Filed:
Dec 18, 2007
Appl. No.:
11/958796
Inventors:
Robert W. Van Holten - Flemington NJ, US
Jagdishchandra C. Patel - Lawrenceville NJ, US
Stephen C. Yeadon - Hampton NJ, US
Jagdishchandra C. Patel - Lawrenceville NJ, US
Stephen C. Yeadon - Hampton NJ, US
Assignee:
Ethicon, Inc. - Somerville NJ
International Classification:
A61F 13/00, A61L 24/00
US Classification:
602 44, 523118, 602 45, 602 48
Abstract:
A hemostatic device comprising (i) a carrier comprising at least one component selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, cellulose acetate phthalate; polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers or combinations thereof; and (ii) thrombin.
Dressing Device
US Patent:
2013013, May 23, 2013
Filed:
Nov 17, 2011
Appl. No.:
13/298495
Inventors:
Robert W. Van Holten - Flemington NJ, US
Xintian Ming - Bridgewater NJ, US
Jerome Riebman - Basking Ridge NJ, US
Xintian Ming - Bridgewater NJ, US
Jerome Riebman - Basking Ridge NJ, US
International Classification:
A61F 13/53, A61K 31/08, A61P 17/02, A01N 25/08, A01P 1/00, A61K 9/70, A01N 47/44
US Classification:
604368, 424445, 514723, 514635, 424409
Abstract:
The invention relates to a transparent, absorbent device for the dressing of wounds and insertion sites of percutaneous and drug delivery devices. The device provides 360 degree or complete circumferential protection of a wound or insertion site of a percutaneous or drug delivery device and comprises a hydrogel center and at least one absorbent material. The hydrogel center can optionally comprise a bioactive agent(s).