Inventors:
Thomas Eugene Christos - Wake Forest NC, US
George S. Amato - Cary NC, US
Robert N. Atkinson - Raleigh NC, US
Maria Graciela Barolli - Morrisville NC, US
Mark J. Suto - Chapel Hill NC, US
International Classification:
A61K 31/4188, C07D 235/00
Abstract:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e. g. , migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e. g. , to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.