ROBERT WESLEY DOMS
Medical Practice in Berwyn, PA
License number
Pennsylvania MD045992L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Berwyn, PA 19312
Professional information
Administration Of An Agent Which Decreases Processing Of Amyloid Precursor Protein
US Patent:
2003018, Oct 2, 2003
Filed:
Jun 28, 1999
Appl. No.:
09/297877
Inventors:
VIRGINIA M.-Y. LEE - PHILADELPHIA PA, US
ROBERT W. DOMS - BERWYN PA, US
ROBERT W. DOMS - BERWYN PA, US
International Classification:
G01N033/53
US Classification:
435/007100
Abstract:
secretase pathways which process amyloid precursor protein into the amyloid peptides of neuritic plaques and vascular deposits that accumulate in the brains of patients with Alzheimer's disease have been identified in the endoplasmic reticulum of neuronal cells. Methods of identifying compounds which increase or decrease processing of amyloid precursor protein via these pathways which may be useful in the treatment of Alzheimer's disease and in identifying causative agents of this disease are provided.
Methods And Compositions For Modulating The Interaction Between The Apj Receptor And The Hiv Virus
US Patent:
6475718, Nov 5, 2002
Filed:
Sep 8, 1998
Appl. No.:
09/149045
Inventors:
Robert W. Doms - Berwyn PA
Daryl Faulds - Mill Valley CA
Joseph E. Hesselgesser - San Francisco CA
Richard Horuk - Belmont CA
Branislava Mitrovic - Walnut Creek CA
Yiqing Zhou - El Sobrante CA
Daryl Faulds - Mill Valley CA
Joseph E. Hesselgesser - San Francisco CA
Richard Horuk - Belmont CA
Branislava Mitrovic - Walnut Creek CA
Yiqing Zhou - El Sobrante CA
Assignee:
Schering Aktiengesellschaft - Berlin
The Trustees of the University of Pennsylvania - Philadelphia PA
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q 170
US Classification:
435 5, 435325, 435352, 435353, 435354, 435358, 435361, 435 4, 435366, 435372, 4353723
Abstract:
The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
Cd4-Independent Hiv Envelope Proteins As Vaccines And Therapeutics
US Patent:
6420545, Jul 16, 2002
Filed:
Jun 22, 1999
Appl. No.:
09/337387
Inventors:
James A. Hoxie - Berwyn PA
Celia C. LaBranche - Chapel Hill NC
Robert W. Doms - Berwyn PA
Trevor L. Hoffman - Lansdowne PA
Celia C. LaBranche - Chapel Hill NC
Robert W. Doms - Berwyn PA
Trevor L. Hoffman - Lansdowne PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
Duke University - Durham NC
Duke University - Durham NC
International Classification:
C07H 2104
US Classification:
536 2372, 4242081, 435 691, 4352351, 4353201, 514 44, 536 231, 536 234, 935 32
Abstract:
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
Oligomeric Hiv-1 Envelope Glycoproteins
US Patent:
6039957, Mar 21, 2000
Filed:
Mar 3, 1997
Appl. No.:
8/805889
Inventors:
Patricia L. Earl - ChevyChase MD
Christopher C. Broder - Rockville MD
Robert W. Doms - Berwyn PA
Bernard Moss - Bethesda MD
Christopher C. Broder - Rockville MD
Robert W. Doms - Berwyn PA
Bernard Moss - Bethesda MD
Assignee:
United States of America, as represented by the Department of Health and
Human Services - Washington DC
Human Services - Washington DC
International Classification:
A61K 3921
US Classification:
4242081
Abstract:
The present invention relates to methods for producing recombinant HIV-1 envelope (env) oligomers for use as immunogens. When gp140 oligomeric glycoproteins were purified by sucrose velocity gradient sedimentation, and then used to immunize mice, the resulting humoral immune response was skewed toward the production of antibodies that recognize conformation-dependent epitopes on the HIV-1 env protein. Assays for HIV-1 infections are described, as well as immonogens for vaccinating against HIV-1 infection.
Lipoparticle Comprising A Protein And Methods Of Making And Using The Same
US Patent:
2012019, Aug 2, 2012
Filed:
Mar 15, 2012
Appl. No.:
13/421559
Inventors:
Robert Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US
International Classification:
A61K 39/12, A61P 37/04, C12N 7/00, A61K 39/395
US Classification:
4241301, 4241991, 4352351
Abstract:
Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
Methods And Compositions For Modulating The Interaction Between The Apj Receptor And The Hiv Virus
US Patent:
2003000, Jan 9, 2003
Filed:
Jun 11, 2002
Appl. No.:
10/166372
Inventors:
Robert Doms - Berwyn PA, US
Daryl Faulds - Mill Valley CA, US
Joseph Hesselgesser - San Francisco CA, US
Richard Horuk - Belmont CA, US
Branislava Mitrovic - Walnut Creek CA, US
Yiqing Zhou - El Sobrante CA, US
Daryl Faulds - Mill Valley CA, US
Joseph Hesselgesser - San Francisco CA, US
Richard Horuk - Belmont CA, US
Branislava Mitrovic - Walnut Creek CA, US
Yiqing Zhou - El Sobrante CA, US
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q001/70, C07K002/00, C07K004/00, C07K005/00, C07K007/00, C07K014/00, C07K016/00, C07K017/00, A61K038/00, C12N005/00, C12N005/02, C12N005/06, C12N005/16
US Classification:
435/345000, 435/325000, 435/005000, 530/300000
Abstract:
The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
Methods And Compositions For Modulating The Interaction Between The Apj Receptor And The Hiv Virus
US Patent:
2003000, Jan 9, 2003
Filed:
Jun 11, 2002
Appl. No.:
10/166357
Inventors:
Robert Doms - Berwyn PA, US
Daryl Faulds - Mill Valley CA, US
Joseph Hesselgesser - San Francisco CA, US
Richard Horuk - Belmont CA, US
Branislava Mitrovic - Walnut Creek CA, US
Yiqing Zhou - El Sobrante CA, US
Daryl Faulds - Mill Valley CA, US
Joseph Hesselgesser - San Francisco CA, US
Richard Horuk - Belmont CA, US
Branislava Mitrovic - Walnut Creek CA, US
Yiqing Zhou - El Sobrante CA, US
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12P021/06, C12N007/00, C12N007/01, C12N007/02, C07K002/00, C07K004/00, C07K005/00, C07K007/00, C07K014/00, C07K016/00, C07K017/00, A61K038/00, C12N005/00, C12N005/02, C12N005/06, C12N005/16
US Classification:
435/235100, 435/325000, 435/239000, 435/069100, 435/345000, 530/300000
Abstract:
The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
Methods And Compositions For Modulating The Interaction Between The Apj Receptor And The Hiv Virus
US Patent:
2003000, Jan 9, 2003
Filed:
Jun 11, 2002
Appl. No.:
10/166113
Inventors:
Robert Doms - Berwyn PA, US
Daryl Faulds - Mill Valley CA, US
Joseph Hesselgesser - San Francisco CA, US
Richard Horuk - Belmont CA, US
Branislava Mitrovic - Walnut Creek CA, US
Yiqing Zhou - El Sobrante CA, US
Daryl Faulds - Mill Valley CA, US
Joseph Hesselgesser - San Francisco CA, US
Richard Horuk - Belmont CA, US
Branislava Mitrovic - Walnut Creek CA, US
Yiqing Zhou - El Sobrante CA, US
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q001/70, C12P021/06, A61K039/395, C07K002/00, C07K004/00, C07K005/00, C07K007/00, C07K014/00, C07K016/00, C07K017/00, A61K038/00, C12N005/00, C12N005/02, C12N005/06, C12N005/16
US Classification:
435/005000, 435/325000, 435/345000, 435/069100, 530/300000, 424/130100
Abstract:
The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
Cd4-Independent Hiv Envelope Proteins As Vaccines And Therapeutics
US Patent:
7371846, May 13, 2008
Filed:
Feb 1, 2005
Appl. No.:
11/048554
Inventors:
James A. Hoxie - Berwyn PA, US
Celia C. LaBranche - Chapel Hill NC, US
Robert W. Doms - Berwyn PA, US
Trevor L. Hoffman - Lansdowne PA, US
Celia C. LaBranche - Chapel Hill NC, US
Robert W. Doms - Berwyn PA, US
Trevor L. Hoffman - Lansdowne PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C07H 21/04
US Classification:
536 2372, 4242081, 435 691, 4352351, 4353201
Abstract:
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
Cd4-Independent Hiv Envelope Proteins As Vaccines And Therapeutics
US Patent:
6849261, Feb 1, 2005
Filed:
Jul 16, 2002
Appl. No.:
10/196515
Inventors:
James A. Hoxie - Berwyn PA, US
Celia C. LaBranche - Chapel Hill NC, US
Robert W. Doms - Berwyn PA, US
Trevor L. Hoffman - Lansdowne PA, US
Celia C. LaBranche - Chapel Hill NC, US
Robert W. Doms - Berwyn PA, US
Trevor L. Hoffman - Lansdowne PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 3921
US Classification:
4242081, 435 691, 4352351, 536 2372
Abstract:
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.