Inventors:
Sangeeta N. Bhatia - Lexington MA, US
David Fernandes Braga Malta - Linda-a-Velha, PT
Nathan Edward Reticker-Flynn - Cambridge MA, US
Gregory H. Underhill - Champaign IL, US
Robert Edward Schwartz - Newton MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
G01N 33/50, C12N 5/0735, C12N 5/09, G01N 33/68, C12N 5/071
US Classification:
506 9, 506 18, 435377, 435395, 435370
Abstract:
The present invention provides arrays comprising polypeptides associated with extracellular matrix that can be used to isolate, differentiate, or culture certain cell types including stem cells, cancer cells, and/or primary hepatocytes. The array comprises at least a pair of polypeptides that comprise a polypeptide associated with extracellular matrix or functional fragments thereof. The invention also provides for methods of diagnosing and/or prognosing a certain disease or disorder through contacting a cell sample from a patient with an array comprising at least a pair of polypeptides that comprise a polypeptide sequence associated with extracellular matrix or functional fragments thereof.