Inventors:
Joseph Tuscano - Folsom CA, US
Derick Lau - Roseville CA, US
Robert O'Donnell - Sacramento CA, US
Yunpeng Ma - Sichuan, CN
Assignee:
UNITED STATES GOVERNMENT AS THE REPRESENTED BY THE - WASHINGTON DC
REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
A61K 38/02, A61K 38/48, A61K 39/395, A61K 38/52, A61P 35/00, C12N 5/09, A61K 38/44
US Classification:
4241741, 514 193, 435375, 514 194, 424 9463, 424 944, 424 945
Abstract:
The present invention provides compositions comprising the component of fermented wheat germ extract (“FWGE”) active in reducing, inhibiting or preventing the proliferation of cancer cells and/or tumors, and methods of making and using such compositions. The active component from FWGE comprises polypeptides having a molecular weight in the range of about 5-100 kiloDaltons (kD), for example, a molecular weight in the range of about 12-50 kD. Exemplary polypeptides from FWGE determined to be active in reducing, inhibiting or preventing the proliferation of cancer cells and/or tumors are listed in Table 1.