DR. ROBERT STEVEN ROSENBAUM
Dentist at Commonwealth Ave, Boston, MA

4588586, May 13, 1986

Jun 18, 1984

6/621792

Jack H. Kessler - Rutherford NJ
Robert S. Rosenbaum - West Roxbury MA

A61K 3748, A61K 3340, C12P 1956, D06M 1600

424 94

The method comprises forming a bactericide having a limited period of bacteriological activity with the bactericide comprising three components including a peroxide, a peroxidase and a source of donor molecules adopted to act as a substrate for the peroxidase; storing the three components in a nonreacting state to maintain the bactericide inactive and admixing the three components in a liquid carrier to cause a catalyzed reaction by said peroxidase for generating free radicals from the source of donor molecules and immersing the contact lens into the solution simultaneously with the admixture. The concentration level of the three components should be selected such that a substantial portion of the peroxide is consumed during the catalyzed reaction.

4473550, Sep 25, 1984

Jan 3, 1983

6/455420

Robert S. Rosenbaum - West Roxbury MA
Jack Kessler - Syracuse NY

A61K 3748, A61K 3340, A61K 31075, C12P 1956

424 94

Bactericidal compositions and methods include the use of a peroxide and a peroxidase in a defined area such as the mouth to rapidly and efficiently kill bacteria. Donor molecules are transformed into bactericidal free radicals which carry out the desired action. The compositions and methods are particularly effective in alleviating gingival disease and periodontal disease.

4919668, Apr 24, 1990

Aug 8, 1988

7/229243

Robert S. Rosenbaum - West Roxbury MA
Noshir R. Menta - Wellesley MA

A61F 230, A61F 212

623 18

A Temporomandibular Joint disc implant for functionally replacing an irreparable human temporomandibular disc formed of a compressible pouch-like body having at least one outer surface layer of resilient biocompatible material enclosing a filling solution or a matrix of fibrous or open-cell material(s) and a filling solution. The fluid forming the filling solution is adapted to be introduced into the body through the surface layer(s) when surgically implanting the disc.

4937072, Jun 26, 1990

Nov 7, 1988

7/268651

Jack H. Kessler - Glen Ellyn IL
Robert S. Rosenbaum - West Roxbury MA

A61K 3750, A61K 3340, A61K 3318, A61L 216

424 944

The method comprises forming a sporocide having a defined period of sporocidal activity comprising three components including a peroxide or peroxide generating material, a peroxidase and a salt of iodide which serves as a donor molecule; storing the three components in a nonreacting state to maintain the sporocide in an inactive state and admixing the three components in a aqueous based carrier to cause a catalyzed reaction by said peroxidase for generating free radicals and/or byproducts from the iodide salt (donor molecule) and contacting the surface or object to be sterilized with the activated mixture. The concentration level of the three components can be selected such that an active sporocidal state is maintained for any desired period of time.

4476108, Oct 9, 1984

Feb 7, 1983

6/464596

Jack H. Kessler - Rutherford NJ
Robert S. Rosenbaum - West Roxbury MA

A61K 728, A61K 720, A61K 3748, A61K 3340

424 50

The bactericidal method of the invention comprises forming a bactericide having a limited period of bacteriological activity with the bactericide including; a peroxide, a peroxidase and a source of donor molecules adapted to act as a substrate for said peroxidase; activating the bactericide to cause a catalyzed reaction by said peroxidase for generating free radicals from said source of donor molecules and simultaneously applying the bactericide for killing bacteria in the treatment of dental disease in situ such as in the oral cavity or as a denture cleaner.