ROBERT S. DANZIGER
Osteopathic Medicine at Taylor St, Chicago, IL

2008002, Jan 31, 2008

Jan 19, 2007

11/625212

Robert Danziger - Chicago IL, US
Randal Skidgel - Winfield IL, US

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - URBANA IL

G01N 33/53, C40B 30/06, C40B 40/10

435007800, 506010000, 506018000

Identification of compositions of biomarkers which diagnose and distinguish between salt-sensitive hypertension, salt-resistant hypertension, salt-independent hypertension and/or hypertensive disorders comprise identifying varying levels of biomarkers in each patient as compared to normal patients. Methods for the identification of novel biomarkers and determination of minimal maximally effective doses of pharmaceutical agents used in treating patients are provided.

2009004, Feb 12, 2009

Feb 22, 2005

10/588673

Robert Danziger - Chicago IL, US

A61K 31/4015, A61P 9/12, A61K 31/44

514352, 514424

This invention provides methods and compositions, most preferably pharmaceutical compositions, for treating salt-sensitive hypertension through the inhibition of certain enzymes in the beta-adrenergic pathway that are involved in the regulation of the secretion of water and sodium. These enzymes are cyclic nucleotide phosphodiesterases (PDE) that selectively hydrolyze the second messenger cAMP and, therefore, down-regulate beta-adrenergic signaling. Specifically provided are methods and pharmaceutical compositions for treating salt-sensitive hypertension by inhibiting certain members of the PDE4 family of cyclic nucleotide phosphodiesterases, particularly members of the PDE4B and PDE4D sub-families and, more particularly, the PDE4B1 and PDE4D5 isotypes thereof.