DR. ROBERT OWEN MCGINNIS, M.D.
Marriage and Family Therapists at Kagy Blvd, Bozeman, MT

2012005, Mar 1, 2012

Sep 13, 2011

13/231651

Ralph Evan McGinnis - Bishops Stortford, GB
Robert Owen McGinnis - Bozeman MT, US

G06F 19/00, C40B 50/00, C40B 30/04

702 19, 506 9, 506 23

Versions of the invention are directed to methods and apparatus for a new type of association-based linkage study technique using bi-allelic markers. The markers used in this technique are chosen so that the least common allele frequencies of the markers vary systematically over a range or subrange of least common allele frequency and the chromosomal location of the markers vary systematically over one or more chromosomal regions or chromosomes to achieve a systematic distribution of the markers over a two-dimensional region that has the orthogonal dimensions of chromosomal location and least common allele frequency. By using the two characteristics or two dimensions of marker chromosomal location and marker allele population frequency in this way, the power and systematic nature of genetic linkage studies using association-based linkage tests is greatly increased. These two-dimensional linkage study techniques increase the power of association studies to localize trait-causing polymorphisms of modest effect.

2012005, Mar 1, 2012

Sep 23, 2011

13/241212

Ralph Evan McGinnis - Bishops Stortford, GB
Robert Owen McGinnis - Bozeman MT, US

G06F 19/18

702 20

Versions of the invention are directed to methods and apparatus for a new type of association-based linkage study technique using bi-allelic markers. The markers used in this technique are chosen so that the least common allele frequencies of the markers vary systematically over a range or subrange of least common allele frequency and the chromosomal location of the markers vary systematically over one or more chromosomal regions or chromosomes to achieve a systematic distribution of the markers over a two-dimensional region that has the orthogonal dimensions of chromosomal location and least common allele frequency. By using the two characteristics or two dimensions of marker chromosomal location and marker allele population frequency in this way, the power and systematic nature of genetic linkage studies using association-based linkage tests is greatly increased. These two-dimensional linkage study techniques increase the power of association studies to localize trait-causing polymorphisms of modest effect.

2002009, Jul 11, 2002

Jan 4, 2002

10/037718

Ralph McGinnis - Bishops Stortford, GB
Robert McGinnis - Bozeman MT, US

C12Q001/68, G06F019/00, G01N033/48, G01N033/50

435/006000, 702/020000

Versions of the invention are directed to methods (and related techniques) for a new type of association based linkage study technique using bi-allelic markers. The markers used in versions of the new linkage studies are chosen using a new two-dimensional concept of “closeness” in terms of marker distribution over a two-dimensional region having the orthogonal dimensions of chromosomal location and least common allele frequency. By using the two characteristics or two dimensions of marker chromosomal location and marker allele population frequency in this unique way, the power and systematic nature of genetic linkage studies using association based linkage tests is greatly increased. These unique two-dimensional linkage study techniques increase the power of association based linkage studies to localize trait causing genes or polymorphisms of modest effect such as human disease causing polymorphisms.