ROBERT MORRIS DOWBEN
Medical Practice in Providence, RI

6677150, Jan 13, 2004

Sep 14, 2001

09/953338

Marlin L. Alford - Dublin TX
Robert M. Dowben - Providence RI

Organ Transport Systems, Inc. - Houston TX

A01N 100

4352841, 4352865, 4352866

This invention is a transportable organ preservation system which substantially increases the time during which the organ can be maintained viable for successful implantation into a human recipient. A chilled oxygenated nutrient solution is pumped through the vascular bed of the organ after excision of the organ from the donor and during transport. The device of the present invention uses flexible permeable tubing to oxygenate the perfusion fluid while the CO produced by the organ diffuses out of the perfusion fluid. One pressurized two liter “C” cylinder that contains 255 liters of oxygen at standard temperature and pressure can supply oxygen for up to 34 hours of perfusion time. The device uses a simple electric pump driven by a storage battery to circulate the perfusion fluid through the organ being transported. The vessel containing the organ to be transported is held at 4° C.

7176015, Feb 13, 2007

Oct 23, 2003

10/692394

Marlin L. Alford - Dublin TX, US
Robert M. Dowben - Providence RI, US

Organ Transport Systems, Inc. - Houston TX

A01N 1/00

4352841, 4352866

This invention is a transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a human recipient. A chilled oxygenated nutrient solution is pumped through the vascular bed of the organ after excision of the organ from the donor and during transport. The device of the present invention uses flexible permeable tubing to oxygenate the perfusion fluid while the COproduced by the organ diffuses out of the perfusion fluid. One pressurized two liter “C” cylinder that contains 255 liters of oxygen at standard temperature and pressure can supply oxygen for up to 34 hours of perfusion time. The device uses a simple electric pump driven by a storage battery to circulate the perfusion fluid through the organ being transported. The vessel containing the organ to be transported is held at 4° C. by coolant blocks.

2008004, Feb 21, 2008

Aug 12, 2005

11/660115

Robert Dowben - Providence RI, US
Martin Alford - Kaufman TX, US

G01N 33/48, G01N 21/17, G01N 21/64

436094000, 356433000, 436172000

Samples are exposed to a fluorescent probe that binds to a known target analyte. Unbound probe is removed and the sample is exposed to a pulsed laser light of preferred wavelength, where the laser light is split into background and sample beams, which are separately measured by two photomultiplier tubes connected to a gated scanning dual channel photon counter Measurements are made by time-resolved photon counting, where individual photons are detected and counted as an electronically synchronized function of the time after each light pulse, and data are summated over a number of light pulses, to detect and quantify the target analyte.

2008003, Feb 14, 2008

Feb 13, 2007

11/674549

Marlin Alford - Dublin TX, US
Robert Dowben - Providence RI, US

A01N 1/02

435284100

This invention is a transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a human recipient. A chilled oxygenated nutrient solution is pumped through the vascular bed of the organ after excision of the organ from the donor and during transport. The device of the present invention uses flexible permeable tubing to oxygenate the perfusion fluid while the CO.sub.2 produced by the organ diffuses out of the perfusion fluid. One pressurized two liter “C” cylinder that contains 255 liters of oxygen at standard temperature and pressure can supply oxygen for up to 34 hours of perfusion time. The device uses a simple electric pump driven by a storage battery to circulate the perfusion fluid through the organ being transported. The vessel containing the organ to be transported is held at 4.degree. C. by coolant blocks.