Inventors:
Dan W. Urry - Birmingham AL
Robert M. Senior - Clayton MO
Assignee:
The University of Alabama at Birmingham - Birmingham AL
International Classification:
A61F 202, A01N 102, A01N 2500, A61K 938
Abstract:
A method of stimulating chemotaxis toward a prosthetic device is disclosed, which method comprises incorporating a chemotactic peptide of the formula
B. sup. 1 -X-(APGVGV). sub. n -Y-B. sup. 2
wherein
A is a peptide-forming residue of L-alanine;
P is a peptide-forming residue of L-proline;
G is a peptide-forming residue of glycine;
V is a peptide-forming residue of L-valine;
B. sup. 1 is H or a biocompatible N-terminal group;
B. sup. 2 is OH, OB. sup. 3 where B. sup. 3 is a non-toxic metal ion, or a biocompatible C-terminal group;
X is PGVGV, GVGV, VGV, GV, V, or a covalent bond;
Y is APGVG, APGV, APG, AP, A, or a covalent bond; and
n is an integer from 1 to 100;
into a surface of the prosthetic device. Prosthetic devices which have the property of enhancing invasion of elastic fiber synthesizing fibroblasts as a result of the chemotactic peptide are also disclosed.