Inventors:
Robert L. Ferris - Pittsburgh PA, US
Pedro Andrade - Pittsburgh PA, US
Andres Lopez-Albaitero - Pittsburgh PA, US
Assignee:
University of Pittsburgh—of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C07K 11/00, A61K 39/39, A61K 38/08, A61K 39/12, C07K 14/71
US Classification:
4241851, 514 193, 514 216, 514939, 530328, 4241841, 4242041, 4242771, 423556, 423303
Abstract:
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, cell comprising the vector, and compositions thereof. The invention also provides a method of inducing a T-cell response in a patient with epithelial cancer, and a method inhibiting epithelial cancer, wherein the methods comprise administering the composition of the invention. The invention further provides a method of stimulating a cell with the inventive polypeptide and a cell so stimulated.