DR. ROBERT LESLIE MONTGOMERY, D.P.M.
Podiatry at Sepulveda Blvd, Los Angeles, CA

5270033, Dec 14, 1993

Aug 18, 1992

7/931684

Robert E. Montgomery - Los Angeles CA

A61K 728, A61K 3750

424 50

A stabilized aqueous dentifrice composition capable of producing or, in the presence of saliva, leading to the production of antimicrobially effective concentrations of hypothiocyanite ions (OSCN--) are herein described. The composition contains both an oxidoreductase enzyme and its specific substrate, for the purpose of producing hydrogen peroxide of at least the minimum effective concentration. The aqueous dentifrice compositions of the present invention can be stabilized against premature enzyme/substrate interaction by controlling the level of dissolved oxygen in the aqueous dentifrice carrier. Optionally, a peroxidase enzyme may be included to act upon the aforementioned hydrogen peroxide, thereby oxidizing salivary thiocyanate ions to produce the antimicrobial concentrations of hypothiocyanite ions (OSCN--). Optionally, thiocyanate ions may also be included in the compositions of this invention in an amount sufficient, together with the other inventive ingredients, to produce in excess of about 100 micromoles/liter/minute of hypothiocyanite ions during use. The amount of water contained in dentifrice compositions is not important to the stability of the composition, provided that the level of oxygen is kept in control.

5176899, Jan 5, 1993

Nov 25, 1991

7/797776

Robert E. Montgomery - Los Angeles CA

A61K 716, A61K 728

424 50

A stabilized aqueous dentifrice composition capable of producing or, in the presence of saliva, leading to the production of antimicrobially effective concentrations of hypothiocyanite ions (OSCN--) are herein described. The composition contains both an oxidoreductase enzyme and its specific substrate, for the purpose of producing hydrogen peroxide of at least the minimum effective concentration. The aqueous dentifrice compositions of the present invention can be stabilized against premature enzyme/substrate interaction by controlling the level of dissolved oxygen in the aqueous dentifrice carrier. Optionally, a peroxidase enzyme may be included to act upon the aforementioned hydrogen peroxide, thereby oxidizing salivary thiocyanate ions to produce the antimicrobial concentrations of hypothiocyanite ions (OSCN--). Optionally, thiocyanate ions may also be included in the compositions of this invention in an amount sufficient, together with the other inventive ingredients, to produce in excess of about 100 micromoles/liter/minute of hypothiocyanite ions during use. The amount of water contained in dentifrice compositions is not important to the stability of the composition, provided that the level of oxygen is kept in control.

5310541, May 10, 1994

Aug 27, 1992

7/936929

Robert E. Montgomery - Los Angeles CA

A61K 728, A61K 3750

424 50

The invention is an animal chew which contains one or more enzymes and substrates for the purpose of generating antimicrobial compounds upon contact with an animal's saliva. The animal chew, primarily made of rawhide, contains an oxidoreductase and substrate, such as, for example, glucose oxidase and glucose, which produces hydrogen peroxide upon being chewed. The hydrogen peroxide activates the salivary peroxide system present in the saliva, which in turn produces hypothiocyanite, a potent antimicrobial agent. The animal chew may also contain added thiocyanate and iodide ions to enhance its antimicrobial activity. The chew is preferably prepared by placing it into a substrate solution for a period, drying the chew, spraying the dried rawhide chew with a solution of the oxidoreductase, and finally drying the chew again.

4863993, Sep 5, 1989

Dec 9, 1987

7/130603

Robert E. Montgomery - Los Angeles CA

OPI Products, Inc. - North Hollywood CA

C08F 2010, C08K 510

524854

An invented composition for promoting the adhesion of adhesives, coatings and/or composites to proteinsceous substrates is disclosed comprising a water-miscible solvent; and an unsaturated caboxylic acid of the general formula: ##STR1## where R. sub. 1 is selected from CH. dbd. CH, C(CH. sub. 3). dbd. C(CH. sub. 3), C(CH. sub. 3). dbd. CH, CH. sub. 2 CH. sub. 2, or CH. sub. 2 CH. sub. 2 CH. sub. 2 ; and R. sub. 2 is selected from a terminally mono-, di-, tri-, or multi- unsaturated group. Methods of making the compound and methods of its use are also disclosed.

4537764, Aug 27, 1985

Jun 6, 1983

6/501383

Michael A. Pellico - Los Angeles CA
Robert E. Montgomery - Los Angeles CA

Laclede Professional Products, Inc. - Gardena CA

A61K 728, A61K 3748, A61K 3750

424 50

An enzymatic dentifrice is provided which contains an enzyme system comprising Beta-D-glucose and glucose oxidase for producing hydrogen peroxide upon oral application of the dentifrice. The enzymatic dentifrice is stabilized against the production of hydrogen peroxide prior to oral application of the dentifrice by limiting any water in the dentifrice to an amount not more than about 10 wt. % based on the weight of the dentifrice.

5603924, Feb 18, 1997

Aug 4, 1995

8/511282

Robert E. Montgomery - Los Angeles CA

OPI Products, Inc.

A61K 7043

424 61

This present invention is a composition for making artificial fingernails which is non-yellowing, and which polymerizes rapidly during use, and a method of making such composition, as well as a method of using the composition in the formation of artificial fingernails. Compositions of this invention comprise a liquid binder portion containing one or more monomeric methacrylate esters; optionally one or more di-, tri-, or multi-functional methacrylate esters, an alcohol, and a tertiary amine accelerator; a polymeric filler portion containing a finely divided polymer, and an organic peroxide polymerization initiator. The compositions of the present invention will polymerize in from about 120 seconds to about 360 seconds, resulting in a hard and resilient non-yellowing polymer.