ROBERT LEROY SACK, MD
Psychiatric at Sam Jackson Park Rd, Portland, OR

6638963, Oct 28, 2003

Apr 29, 1997

08/840382

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

Oregon Health and Science University - Portland OR

A61K 3140

514415, 514416, 514418, 514419, 548491, 548494, 548495, 548496

A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin, melatonin agonists or compounds that stimulate endogenous melatonin production so that the durations of the effective plasma concentrations of melatonin, melatonin agonists or compounds that stimulate endogenous melatonin production overlap with onset or offset of pre-treatment endogenous melatonin production, to provide a circadian-rhythm phase advance or phase delay, respectively. The methods of the invention also provide for concentration and/or duration of the effective plasma concentrations of melatonin, melatonin agonists or compounds that stimulate endogenous melatonin production to be greater in the time interval between about 8 hours before the dim light endogenous melatonin onset (DLMO) to about 4 hours after DLMO than in the time interval from about 4 hours after DLMO to about 8 hours before DLMO to achieve a circadian-rhythm phase advance. The methods of the invention also provide for concentration and/or duration of the effective plasma concentrations of melatonin, melatonin agonists or compounds that stimulate endogenous melatonin production to be greater in the time interval between about 4 hours after DLMO to about 8 hours before DLMO than in the time interval from about 8 hours before DLMO time to about 4 hours after DLMO to achieve a circadian-rhythm phase delay. In addition, the invention provides methods for regulating a humans exposure to light and dark to prevent or enhance, respectively, the humans endogenous production of melatonin.

6794407, Sep 21, 2004

Jul 23, 2002

10/202645

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

Oregon Health and Sciences University - Portland OR

A61K 3140

514415, 514416, 514418, 514419, 548491, 548494, 548495, 548496, 548507

A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined with relation to the time of dim light endogenous melatonin onset. Embodiments capable of alleviating the effects of jet lag, winter depression and shift-work sleep disturbance are provided.

6423738, Jul 23, 2002

May 30, 2000

09/580075

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

Oregon Health Sciences University - Portland OH

A61K 3140

514415, 514416, 514418, 514419, 548491, 548494, 548495, 548496

A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined with relation to the time of dim light endogenous melatonin onset. Embodiments capable of alleviating the effects of jet lag, winter depression and shift-work sleep disturbance are provided.

6069164, May 30, 2000

Jan 6, 1997

8/778842

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

Oregon Health Sciences University - Portland OR

A61K 3140, A61K 31405

514415

A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined with relation to the time of dim light endogenous melatonin onset. Embodiments capable of alleviating the effects of jet lag, winter depression and shiftwork sleep disturbance are provided.

5707652, Jan 13, 1998

Jun 7, 1995

8/480558

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR
Keith A. Parrott - Corvallis OR
James W. Ayres - Corvallis OR

State of Oregon - Portland OR

A61K 952, A61K 954, A61K 922, A61K 926

424457

Methods for treating circadian rhythm disorders and sleep disorders are described. The method involves oral administration of a sustained release composition of melatonin to produce a normal melatonin pattern when the normal pattern has been disrupted or is missing.

5242941, Sep 7, 1993

Feb 25, 1992

7/842723

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

State of Oregon - Portland OR

A61K 3140

514416

A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin from about 6 hours to about 19 hours prior to when the normal sleep phase should begin, depending on whether a phase advance shift in circadian rhythms or a phase delay shift is desired. This is typically from about 4 hours to about 17 hours prior to the time of endogenous melatonin onset.

5591768, Jan 7, 1997

Aug 24, 1993

8/110878

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

State of Oregan, Acting by and Through the Oregon State Board of Higher
Education on Behalf of the Oregon Health Sciences University - Portland OR

A61K 3140, A61K 31405

514415

A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined with relation to the time of dim light endogenous melatonin onset. Embodiments capable of alleviating the effects of jet lag, winter depression and shift-work sleep disturbance are provided.

2006016, Jul 27, 2006

Sep 21, 2004

10/945843

Alfred Lewy - Portland OR, US
Robert Sack - Portland OR, US

A61K 9/22, A61K 31/405

424468000, 514419000

A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined with relation to the time of dim light endogenous melatonin onset. Embodiments capable of alleviating the effects of jet lag, winter depression and shift-work sleep disturbance are,provided.

5716978, Feb 10, 1998

May 30, 1995

8/454545

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

State of Oregon - Portland OR

A61K 3140

514415

A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin from about 6 hours to about 19 hours prior to when the normal sleep phase should begin, depending on whether a phase advance shift in circadian rhythms or a phase delay shift is desired. This is typically from about 4 hours to about 17 hours prior to the time of endogenous melatonin onset.