Inventors:
DAVID BOTSTEIN - BELMONT CA, US
ROBERT L. COHEN - SAN MATEO CA, US
AUDREY D. GODDARD - SAN FRANCISCO CA, US
AUSTIN L. GURNEY - BELMONT CA, US
KENNETH J. HILLAN - SAN FRANCISCO CA, US
DAVID A. LAWRENCE - SAN FRANCISCO CA, US
ARNOLD J. LEVINE - NEW YORK NY, US
DIANE PENNICA - BURLINGAME CA, US
MARGARET ANN ROY - SAN FRANCISCO CA, US
WILLIAM I. WOOD - HILLSBOROUGH CA, US
International Classification:
A61K 39/395, A61P 35/00
US Classification:
4241331, 4241301, 4241391, 4241421
Abstract:
Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.