ROBERT L SAFIRSTEIN, MD
Osteopathic Medicine at 7 St, Little Rock, AR
License number
Arkansas E-3134
Category
Osteopathic Medicine
Type
Nephrology
Address
Address
4300 W 7Th St, Little Rock, AR 72205
Phone
(501) 257-5866
(501) 257-5867 (Fax)
(501) 666-2352
(501) 257-5867 (Fax)
(501) 666-2352
Personal information
See more information about ROBERT L SAFIRSTEIN at radaris.comName
Address
Phone
Little Rock, AR
5800 Edgewood Rd, Little Rock, AR 72207
Professional information
Robert Safirstein, Little Rock AR
Specialties:
Internal Medicine, Nephrology
Work:
University of Arkansas
4301 W Markham St, Little Rock, AR 72205
4301 W Markham St, Little Rock, AR 72205
Education:
University of Cincinnati (1969)
Dr. Robert L Safirstein, West Haven CT - MD (Doctor of Medicine)
Specialties:
Internal Medicine
Address:
950 Campbell Ave, West Haven 06516
(203) 932-5711 (Phone)
VA MEDICAL CENTER
4300 W 7Th St, Little Rock 72205
(501) 257-5866 (Phone), (501) 257-5867 (Fax)
(203) 932-5711 (Phone)
VA MEDICAL CENTER
4300 W 7Th St, Little Rock 72205
(501) 257-5866 (Phone), (501) 257-5867 (Fax)
Certifications:
Internal Medicine, 1974
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
University of Cincinnati / Main Campus
Graduated: 1969
New York-Presbyterian Hospital
Mount Sinai Hospital
Usphs
Yale University School Of Medicine
University of Cincinnati / Main Campus
Graduated: 1969
New York-Presbyterian Hospital
Mount Sinai Hospital
Usphs
Yale University School Of Medicine
Regulation Of The P21 Gene And Uses Thereof
US Patent:
2002010, Aug 8, 2002
Filed:
Jun 14, 2001
Appl. No.:
09/881635
Inventors:
Peter Price - Little Rock AR, US
Judit Megyesi - Little Rock AR, US
Robert Safirstein - Little Rock AR, US
Judit Megyesi - Little Rock AR, US
Robert Safirstein - Little Rock AR, US
International Classification:
A61K031/00
US Classification:
514/001000
Abstract:
The present invention provides a method for treating or preventing a pathophysiological state of an organ in an individual wherein this state is characterized by an undesirable level of cyclin-dependent kinase inhibitor activity in the organ, comprising the step of regulating the expression of the pgene in the organ of the individual. Also provided is a method for treating chronic progressive renal failure in an individual in need of such treatment, comprising the step of regulating the expression of the pgene in one or both kidneys of the individual wherein the regulation of the pgene results in the manipulation of cyclin-dependent kinase inhibitor activity in one or both kidneys. In addition there is provided a method of lowering the rate of long-term rejection of a transplanted organ in an individual comprising the step of transplanting into the individual the organ from a donor wherein the pgene in the organ is not expressed.
Regulation Of The P21 Gene And Uses Thereof
US Patent:
2005025, Nov 10, 2005
Filed:
Apr 22, 2005
Appl. No.:
11/112354
Inventors:
Peter Price - Little Rock AR, US
Judit Megyesi - Little Rock AR, US
Robert Safirstein - Little Rock AR, US
Judit Megyesi - Little Rock AR, US
Robert Safirstein - Little Rock AR, US
International Classification:
A61K048/00, A61K031/19
US Classification:
514044000, 514569000, 514557000, 514575000
Abstract:
The present invention in general is directed to methods for manipulating cyclin-dependent kinase inhibitor activity. Such manipulation will reduce or eliminate the expression of p21 gene based on specific requirements. This will be helpful in treating or preventing pathophysiological state in an individual which is characterized by undesirable level of cyclin-dependent kinase inhibitor activity, treating chronic progessive renal failure or lowering the rate of long-term rejection of a transplated organ in an individual. Additionally, the present invention also teaches up-regulating the expression of p21 gene using histone deacetylase inhibitors. The use of such inhibitors alone will be be helpful in treating acute renal failures whereas in combination with chemotherapeutic drugs will enhance the therapeutic potential of such drugs.