ROBERT KNOX DICKSON
Pilots at Nicholasville Rd, Lexington, KY
License number
Kentucky A2446360
Issued Date
Apr 2016
Expiration Date
Oct 2016
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
2121 Nicholasville Rd APT 604, Lexington, KY 40503
Professional information
Fungal Ipc Synthase Assay
US Patent:
6022684, Feb 8, 2000
Filed:
Oct 6, 1997
Appl. No.:
8/944594
Inventors:
Jeffrey Radding - Carmel IN
Robert C. Dickson - Lexington KY
Robert L. Lester - Lexington KY
Robert C. Dickson - Lexington KY
Robert L. Lester - Lexington KY
Assignee:
University of Kentucky Research Foundation - Lexington KY
Eli Lilly and Company - Indianapolis IN
Eli Lilly and Company - Indianapolis IN
International Classification:
C12Q 100, C12Q 102
US Classification:
435 4
Abstract:
The presently-disclosed IPC synthase-inhibitor assays comprise the steps of: (1) expression of the IPC1 gene in a cell; (2) introducing labeled starting substrates for ceramide conversion as well as potential inhibitor(s) of such conversion to the expressed gene product in an environment which allows time and conditions for conversion, and (3) identifying those potential inhibitors which actually inhibit conversion. The present invention also provides methods to determine the ability of a test compound to inhibit fungal growth, comprising the steps of (1) presenting active inositolphosophotidylceramide synthase in a manner such that synthesis of inositolphosphotidylceramide can occur; (2) introducing ceramide and phosphotylinositol, said ceramide or phosphatidylinositol carrying label for identification; (3) subjecting said active inositolphosophotidylceramide synthase, ceramide and phosphotylinositol to ordinary conditions necessary for ceramide conversion to phosphoinositol ceramide; and (4) identifying those test compounds which inhibit ceramide conversion to phosphoinositol ceramide.
Method For Obtaining Antifungal And Herbicidal Compounds That Target The First Committed Step In Shingolipid Long-Chain Base Biosynthesis
US Patent:
5583030, Dec 10, 1996
Filed:
Dec 28, 1994
Appl. No.:
8/365981
Inventors:
Robert C. Dickson - Lexington KY
Robert L. Lester - Lexington KY
Robert L. Lester - Lexington KY
Assignee:
The University of Kentucky Research Foundation - Lexington KY
International Classification:
C12N 115, C12N 119, C12N 121, C12N 510, C12N 1554, C12N 1563
US Classification:
4352401
Abstract:
The invention provides the LCB1 and LCB2 genes of the yeast Saccharomyces cerevisiae that encode subunits of the enzyme serine palmitoyltransferase (SPT), the first enzyme leading to synthesis of the long-base component of the sphingolipids. The present specification describes the isolation of the LCB1 and LCB2 genes. The invention further relates to methods of using these genes to either inhibit SPT activity or to inhibit synthesis of the enzyme. Furthermore, the invention relates to methods for constructing strains of S. cerevisiae or other organisms that can be used to select and to test for compounds that either inhibit SPT activity or to inhibit synthesis of the enzyme.
Technique For Specifying The Fatty Acid At The Sn2 Position Of Acylglycerol Lipids
US Patent:
5869304, Feb 9, 1999
Filed:
Oct 12, 1994
Appl. No.:
8/321670
Inventors:
Robert C. Dickson - Lexington KY
Robert L. Lester - Lexington KY
M. Marek Nagiec - Lexington KY
Robert L. Lester - Lexington KY
M. Marek Nagiec - Lexington KY
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
C12N 1563, C07H 2104
US Classification:
4351723
Abstract:
A method for specifying a fatty acid at the sn2 position of acylglycerol lipids including (a) transfecting a vector including the SLC1 gene or a variant thereof into embryonic biological material, and (b) allowing the SLC1 gene to specify the type of fatty acid at the sn2 position of acylglycerol lipids. Also provided for is an isolated SLC1 gene and a probe for its detection.
Lac+ Saccharomyces Cerevisiae
US Patent:
5047340, Sep 10, 1991
Filed:
Oct 18, 1988
Appl. No.:
7/260124
Inventors:
Robert C. Dickson - Lexington KY
Kotikanyadanam K. Sreekrishna - Bartlesville OK
Kotikanyadanam K. Sreekrishna - Bartlesville OK
Assignee:
The University of Kentucky Research Foundation - Lexington KY
International Classification:
C12P 2100, C12P 2102, C12N 500
US Classification:
435161
Abstract:
The invention relates to novel, transformed strains of Lac. sup. + Saccharomyces cerevisiae, capable of utilizing lactose as a sole carbon source, produced by inserting into the Saccharomyces cerevisiae a plasmid containing a lactose permease and a beta-galactosidase gene derived from Kluyveromyces lactis yeast.