Inventors:
Roderick Davis - Durham NC, US
Robert Johnson - Durham NC, US
Aaren Miller - Durham NC, US
James Way - Durham NC, US
Shawn Williams - Durham NC, US
Timothy Willson - Durham NC, US
George Wisely - Durham NC, US
Ann Kontz - Wilmington NC, US
International Classification:
C07K014/72, G06F019/00, G01N033/48, G01N033/50
Abstract:
A solved three-dimensional crystal structure of an HNF4g ligand binding domain polypeptide is disclosed, along with a crystal form of the HNF4g ligand binding domain. Methods of designing modulators of the biological activity of HNF4g, and other HNF4 ligand binding domain polypeptides are also disclosed.