Inventors:
Steven Pruitt - Williamsville NY, US
Alexander Maslov - Williamsville NY, US
Tara Barone - Snyder NY, US
Robert Plunkett - Orchard Park NY, US
International Classification:
A01K067/027, C12N005/06, C12N005/08
US Classification:
800018000, 435366000, 435354000
Abstract:
The present invention provides methods and compositions for identifying stem cells and/or cancer cells in non-human animals. The compositions include vectors comprising elements suitable for integration into a licensing factor gene such that a cell harboring the chromosome into which the vector elements have integrated expresses a reporter transgene. The methods comprise the detection of stem and/or cancer cells by detecting the expression of the reporter transgene.