ROBERT J NELSON
Broker in Boston, MA

4940883, Jul 10, 1990

Apr 24, 1989

7/342989

Barry L. Karger - Newton MA
Robert J. Nelson - Boston MA

Northeastern University - Boston MA

H05B 302

219200

A window burner for creating windows by selective removal of polymer type coatings from capillary columns and very small diameter tubes. The burner includes an electric circuit which provides a predetermined, controlled current from a standard 120 or 220 volt AC outlet. The predetermined, controlled current electrically heats a resistive wire for a predetermined period of time. The resistive wire may have a predetermined configuration to facilitate mounting of the capillary column for selective burning. The size of the resistive wire and the predetermined period of time during which the predetermined, controlled current is provided thereto are factors determining the size of the window formed by selectively burning off the polymer coating.

5085757, Feb 4, 1992

Aug 28, 1989

7/399600

Barry L. Karger - Newton MA
Robert J. Nelson - Boston MA

Northeastern University - Boston MA

G01N 2726, B01D 5702

204299R

An integrated temperature control/alignment system for use with a high performance capillary electrophoretic apparatus comprises a complementary pair of capillary column mounting plates formed from an electrically insulative, high thermal conductivity material for mounting a capillary column. The first mounting plate includes a well having a predetermined circumference, first and second grooves contiguous with the well and ports formed in the grooves and extending through the plate. The second mounting plate includes a plug configured for insertion in the well and ports aligned with the ports of the first mounting plate. Respective ends of the capillary column are seated and locked in the grooves to preposition the capillary column with respect to the ports. Capillary columns of varying lengths may be mounted within the mounting plates by coiling the intermediate portion thereof within the well to increase or decrease the working length of the column in predetermined increments, depending upon the particular application. Optical coupling elements are disposed in the ports to couple sampling and reference radiation to and from the mounted capillary column.

4898658, Feb 6, 1990

Nov 25, 1987

7/125539

Barry L. Karger - Newton MA
Aran Paulus - Boston MA
Aharon S. Cohen - Brookline MA
Robert J. Nelson - Boston MA

Northeastern University - Boston MA

G01N 2726

204299R

An integrated temperature control/alignment system for use with a high performance capillary electrophoretic apparatus is disclosed. In one exemplary embodiment the integrated temperature control/alignment system comprises a pair of capillary column mounting plates for mounting a capillary column as a constituent of the electrophoretic apparatus, a pair of secondary support plates, a pair of thermoelectric plates and external heat sink plates. Detection openings are formed in each of the plates as required so that a continuous detection path exists through the integrated temperature control/alignment system. The capillary column is seated and locked in grooves formed in the capillary column mounting plates so that the detection windows of the capillary column are coordinated with the aligned detection openings formed in the applicable plates of the integrated temperature control/alignment system. The temperature of substantially the entire capillary column, including the detection zone, is controlled or regulated by the temperatures of the thermoelectric plates which comprise one or more thermoelectric circuits utilizing the Peltier effect. Regulation of current flow in the thermoelectric plates controls the temperature effect exerted by the thermoelectric plates, thereby controlling both the direction and rate of heat transfer with the capillary column.