ROBERT INNIS
Psychiatric at Mimosa Farm Ct, Rockville, MD
License number
Maryland D0056635
Category
Psychiatric
Type
Psychiatry
Address
Address
13016 Mimosa Farm Ct, Rockville, MD 20850
Phone
(240) 453-0776
(310) 693-2979 (Fax)
(310) 693-2979 (Fax)
Personal information
See more information about ROBERT INNIS at radaris.comName
Address
Phone
705 Americana Dr APT 21, Annapolis, MD 21403
901 E Lombard St APT 301, Baltimore, MD 21202
13016 Mimosa Farm Ct, Rockville, MD 20850
930 Bay Forest Ct, Annapolis, MD 21403
13016 Mimosa Farm Ct, Rockville, MD 20850
Professional information
Beta-Amyloid Pet Imaging Agents
US Patent:
2011000, Jan 13, 2011
Filed:
Apr 19, 2007
Appl. No.:
12/293340
Inventors:
Lisheng Cai - Derwood MD, US
Victor W. Pike - Bethesda MD, US
Robert B. Innis - Rockville MD, US
Victor W. Pike - Bethesda MD, US
Robert B. Innis - Rockville MD, US
Assignee:
THE DEPARTMENT OF HEALTH AND HUMAN SERVICES - Rockville MD
International Classification:
A61K 49/00, C07D 471/04, C07D 277/66
US Classification:
424 91, 546121, 548178
Abstract:
Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.
Method Of Determining The Activity Of A Central Nervous System Drug On Striatal Dopamine Transporter Populations
US Patent:
2003013, Jul 10, 2003
Filed:
Dec 31, 2002
Appl. No.:
10/334239
Inventors:
Peter Snyder - West Hartford CT, US
Robert Innis - Rockville MD, US
John Seibyl - Branford CT, US
Akira Kugaya - New Haven CT, US
Stephen Williams - Stonington CT, US
Robert Innis - Rockville MD, US
John Seibyl - Branford CT, US
Akira Kugaya - New Haven CT, US
Stephen Williams - Stonington CT, US
Assignee:
Pfizer Inc.
International Classification:
A61K051/00, A61K031/405
US Classification:
514/419000, 424/001110
Abstract:
This invention relates to a method of predicting the activity of a CNS drug on striatal dopamine transporter populations. The method uses SPECT brain imaging to predict the activity of antidepressants or anxiolytic agents on striatal dopamine transporter populations. The method uses the increase in dopamine transporter populations as a marker for predicting sexual dysfunction side effects, as well as to determine proper dosing for antidepressants or anxiolytics agents in order to avoid the sexual dysfunction side effects.
Tropane Analogs Binding To Monoamine Transporters
US Patent:
2003001, Jan 16, 2003
Filed:
Jun 11, 2001
Appl. No.:
09/878450
Inventors:
Gilles Tamagnan - Woodbridge CT, US
Xing Fu - West Haven CT, US
Ronald Baldwin - Guilford CT, US
Robert Innis - Rockville MD, US
Xing Fu - West Haven CT, US
Ronald Baldwin - Guilford CT, US
Robert Innis - Rockville MD, US
International Classification:
C07D451/02
US Classification:
546/124000, 546/125000
Abstract:
The present invention is directed to a tropane analog having the structure (I)
wherein Ar is a selected substituted or unsubstituted aryl group; G COCH, COR, or CH CHR; X H, I, Br, Cl, F, NO, COR, or, NH; R H or a substituted or unsubstituted lower alkyl group; and Z O, S, or N. The tropane analogs of the invention bind to monoamine transporters in the mammalian brain, and are useful as diagnostic tools for analyzing the role of monoamine transporters in diseases such as depression, schizophrenia, major depression, attention-deficit hyperactivity disorder, obesity, obsessive compulsive disorders, and cocaine addiction.
Transition Metal-Cyclopentadienyl-Tropane Conjugates
US Patent:
2002011, Aug 15, 2002
Filed:
Dec 1, 2000
Appl. No.:
09/727076
Inventors:
Gilles Tamagnan - Woodbridge CT, US
Ronald Baldwin - Guilford CT, US
Robert Innis - Rockville MD, US
Ronald Baldwin - Guilford CT, US
Robert Innis - Rockville MD, US
International Classification:
C07F013/00
US Classification:
546/010000, 534/014000
Abstract:
Transition metal-cyclopentadienyl-tropane conjugate compounds are described. Methods for preparing transition metal-cyclopentadienyl-tropane conjugate compounds are also described. Transition metal-cyclopentadienyl-tropane conjugate compounds of the invention exhibit an affinity for monoamine transporters and are useful as diagnostic and/or therapeutic agents.
Radiotracers For Imaging P-Glycoprotein Function
US Patent:
7989630, Aug 2, 2011
Filed:
Apr 30, 2008
Appl. No.:
12/112994
Inventors:
Victor W. Pike - Bethesda MD, US
Robert B. Innis - Rockville MD, US
Sami S. Zoghbi - Great Falls VA, US
Neva Lazarova - Toronto, CA
Robert B. Innis - Rockville MD, US
Sami S. Zoghbi - Great Falls VA, US
Neva Lazarova - Toronto, CA
Assignee:
National Institutes of Health Represented by the Secretary of the Department of Health and Human Services, National Institutes of Health - Washington DC
International Classification:
C07D 211/52, A61K 31/451
US Classification:
546217, 514327
Abstract:
P-glycoprotein transporter (P-gp) acts as a pump at the blood-brain barrier to exclude a wide range of xenobiotics (e. g. , toxins, drugs, etc. ) from the brain and is also expressed in a tumor in response to exposure to established or prospective chemotherapeutics (a phenomenon known as multidrug resistance). This invention concerns the preparation and use of radiotracers for imaging P-gp function in vitro and in vivo. Radiotracers of the present invention are avid substrates for P-gp and have structures based on N-Desmethyl-loperamide.