Inventors:
John E. Van Hamont - Fort Meade MD, US
Phil Friden - Bedford MA, US
Robert H. Reid - Fairfield PA, US
F. Donald Roberts - Dover MA, US
Charles E. McQueen - Olney MD, US
Jean A. Setterstrom - Silver Spring MD, US
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 9/14, A61K 9/16, A61K 9/50
US Classification:
424490, 424489, 424491, 424493, 424496, 424501
Abstract:
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.