ROBERT G. MARTINDALE, MD
Radiology at Sam Jackson Park Rd, Portland, OR
License number
Oregon MD25790
Category
Radiology
Type
Surgery
Address
Address
3181 SW Sam Jackson Park Rd, Portland, OR 97239
Phone
(503) 494-9145
Personal information
See more information about ROBERT G. MARTINDALE at radaris.comName
Address
Phone
619 NW Alpine Ter, Portland, OR 97210
PO Box 1212, Coos Bay, OR 97420
780 8Th St SW, Bandon, OR 97411
1592 E Chamberlain Ave, Cottage Grove, OR 97424
2275 Ibsen Ave, Cottage Grove, OR 97424
Organization information
See more information about ROBERT G. MARTINDALE at bizstanding.comOregon Health & Science University - Robert G Martindale MD
3181 SW Sam Jackson Park Rd, Portland, OR 97239
Categories:
General Surgeons, Physicians & Surgeons
Phone:
(503) 494-6900 (Phone)
Professional information
Robert G Martindale, Portland OR
Specialties:
Surgeon
Address:
3181 Sw Sam Jackson Park Rd, Portland, OR 97239
Board certifications:
American Board of Surgery Certification in Surgery
Robert George Martindale, Portland OR
Specialties:
Surgery, Medical Oncology
Work:
Digestive Health Center
3303 SW Bond Ave, Portland, OR 97239 Oregon Health & Science University
3181 SW Sam Jackson Park Rd, Portland, OR 97239
3303 SW Bond Ave, Portland, OR 97239 Oregon Health & Science University
3181 SW Sam Jackson Park Rd, Portland, OR 97239
Education:
George Washington University (1984)
Prodrugs Of Short-Chain Fatty Acids And Treatment Methods
US Patent:
2009012, May 14, 2009
Filed:
Jan 17, 2006
Appl. No.:
11/813343
Inventors:
Vadivel Ganapathy - Martinez GA, US
Puttur D. Prasad - Martinez GA, US
Robert G. Martindale - Portland OR, US
Puttur D. Prasad - Martinez GA, US
Robert G. Martindale - Portland OR, US
Assignee:
Medical College of Georgia Research Institute - Augusta GA
International Classification:
A61K 9/12, C07C 69/675, A61K 31/221, A61P 35/00, C07H 19/04, A61K 31/7052
US Classification:
424 45, 560129, 514546, 536 221, 514 43
Abstract:
Prodrugs made up of biologically-active short-chain fatty acids or derivatives thereof conjugated to neutral or cationic amino acids capable of intracellular transport by ATB, are provided. The short-chain fatty acid or derivative thereof can be attached to the amino acid through a hydroxyl group of the amino acid to form a fatty acid ester of the amino acid, or it can be attached through the amino group of the amino acid to form a fatty-acid amide of the amino acid. Serine butyrate (O-butyryl serine) is a preferred prodrug. These prodrugs are useful for treatment of colon cancer, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lung cancer, cervical cancer, and cancers resulting from metastases from primary colon cancer sites. Methods of delivering biologically-active short-chain fatty acids or derivatives thereof to cells in need of these molecules and methods of treating diseases using the prodrugs of this invention are also provided.
Prodrugs Of Short-Chain Fatty Acids And Treatment Methods
US Patent:
8518989, Aug 27, 2013
Filed:
Mar 3, 2011
Appl. No.:
13/039661
Inventors:
Vadivel Ganapathy - Martinez GA, US
Puttur D. Prasad - Martinez GA, US
Robert G. Martindale - Portland OR, US
Puttur D. Prasad - Martinez GA, US
Robert G. Martindale - Portland OR, US
Assignee:
Georgia Health Sciences University Research Institute, Inc. - Augusta GA
International Classification:
A61K 31/22, A61K 31/16
US Classification:
514551, 514629
Abstract:
Prodrugs made up of biologically-active short-chain fatty acids or derivatives thereof conjugated to neutral or cationic amino acids capable of intracellular transport by ATB, are provided. The short-chain fatty acid or derivative thereof can be attached to the amino acid through a hydroxyl group of the amino acid to form a fatty acid ester of the amino acid, or it can be attached through the amino group of the amino acid to form a fatty-acid amide of the amino acid. Serine butyrate (O-butyryl serine) is a preferred prodrug. These prodrugs are useful for treatment of colon cancer, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lung cancer, cervical cancer, and cancers resulting from metastases from primary colon cancer sites. Methods of delivering biologically-active short-chain fatty acids or derivatives thereof to cells in need of these molecules and methods of treating diseases using the prodrugs of this invention are also provided.