Robert F Hughes
Engineers in San Diego, CA
License number
Utah 173898-2202
Issued Date
Jun 3, 1988
Expiration Date
Apr 30, 1994
Category
Engineer/Land Surveyor
Type
Professional Engineer
Address
Address
San Diego, CA
Professional information
Robert Hughes - San Diego, CA
Work:
Applied Research Associates, Inc. San Diego Office
Senior Mechanical Engineer University of California, San Diego - San Diego, CA
Teaching Assistant Lockheed Martin STS
Mechanical Engineer Asc Skyepharma - San Diego, CA
CAD Specialist University of California, San Diego & SPAWAR Systems Center
Student Project Engineer University of California, San Diego - San Diego, CA
Student Research Engineer
Senior Mechanical Engineer University of California, San Diego - San Diego, CA
Teaching Assistant Lockheed Martin STS
Mechanical Engineer Asc Skyepharma - San Diego, CA
CAD Specialist University of California, San Diego & SPAWAR Systems Center
Student Project Engineer University of California, San Diego - San Diego, CA
Student Research Engineer
Education:
University of California - San Diego, CA
Master of Science in Mechanical Engineering University of California - San Diego, CA
BS in Mechanical Engineering
Master of Science in Mechanical Engineering University of California - San Diego, CA
BS in Mechanical Engineering
Skills:
Computer Aided Drafting and Design (Solidworks and many other CAD systems), Matlab, Labview, MS Office, MS Project,
Marketing Strategist, Brand Advocate, Media Business Entrepreneur
Position:
CEO at Synergy Social Media, Chairman/CEO at KPRI - Compass Radio Group
Location:
Greater San Diego Area
Industry:
Marketing and Advertising
Work:
Synergy Social Media
since Jan 2011
-
CEO
KPRI - Compass Radio Group
since Jan 1991
-
Chairman/CEO
Robert Hughes - San Diego, CA
Work:
American Preferred Lending
Senior Loan Consultant Lawrence Welk Resort - Escondido, CA
Tour Host Ashford University - San Diego, CA
Enrollment Advisor - Team Lead Great Western/Miracle Link Mortgage - San Diego, CA
Sales Manager/Partner
Senior Loan Consultant Lawrence Welk Resort - Escondido, CA
Tour Host Ashford University - San Diego, CA
Enrollment Advisor - Team Lead Great Western/Miracle Link Mortgage - San Diego, CA
Sales Manager/Partner
Education:
Ashford University
Bachelor's in Organizational Management
Bachelor's in Organizational Management
Recruiter At Ashely Biologics
Position:
Recruiter at Ashely Biologics
Location:
Greater San Diego Area
Industry:
Biotechnology
Work:
Ashely Biologics
-
Recruiter
Compounds Useful As Inhibitors Of Atr Kinase
US Patent:
2013008, Apr 11, 2013
Filed:
Sep 28, 2012
Appl. No.:
13/631732
Inventors:
Jean-Damien Charrier - Grove, GB
Pierre-Henri Storck - Abingdon, GB
John Studley - Witney, GB
Francoise Yvonne Theodora Marie Pierard - Abingdon, GB
Steven John Durrant - Abingdon, GB
Benjamin Joseph Littler - Carlsbad CA, US
Paul Angell - Carlsbad CA, US
Robert Michael Hughes - San Diego CA, US
David Andrew Siesel - San Diego CA, US
Armando Urbina - San Diego CA, US
Carl Zwicker - Brighton MA, US
Nicholas LoConte - Winthrop MA, US
Timothy Barder - Arlington MA, US
Pierre-Henri Storck - Abingdon, GB
John Studley - Witney, GB
Francoise Yvonne Theodora Marie Pierard - Abingdon, GB
Steven John Durrant - Abingdon, GB
Benjamin Joseph Littler - Carlsbad CA, US
Paul Angell - Carlsbad CA, US
Robert Michael Hughes - San Diego CA, US
David Andrew Siesel - San Diego CA, US
Armando Urbina - San Diego CA, US
Carl Zwicker - Brighton MA, US
Nicholas LoConte - Winthrop MA, US
Timothy Barder - Arlington MA, US
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA
International Classification:
C07D 413/14, A61K 45/06, A61N 5/10, A61K 31/4745, A61K 31/7068, A61K 31/497, A61K 33/24
US Classification:
424649, 544405, 51425505, 514 49, 435184, 600 1
Abstract:
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I-1:wherein the variables are as defined herein.Additionally, the compounds of this invention have formula II:or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.
Processes For Making Compounds Useful As Inhibitors Of Atr Kinase
US Patent:
2013018, Jul 18, 2013
Filed:
Sep 28, 2012
Appl. No.:
13/631759
Inventors:
Jean-Damien Charrier - Wantage, GB
John Studley - Witney, GB
Francoise Yvonne Theodora Marie Pierard - Abingdon, GB
Steven John Durrant - Abingdon, GB
Benjamin Joseph Littler - Carlsbad CA, US
Robert Michael Hughes - San Diego CA, US
David Andrew Siesel - San Diego CA, US
Paul Angell - , US
Armando Urbina - San Diego CA, US
Yi Shi - Natick MA, US
John Studley - Witney, GB
Francoise Yvonne Theodora Marie Pierard - Abingdon, GB
Steven John Durrant - Abingdon, GB
Benjamin Joseph Littler - Carlsbad CA, US
Robert Michael Hughes - San Diego CA, US
David Andrew Siesel - San Diego CA, US
Paul Angell - , US
Armando Urbina - San Diego CA, US
Yi Shi - Natick MA, US
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA
International Classification:
C07D 413/04, C07D 413/14, C07D 241/20, C07C 251/48
US Classification:
51425505, 564265, 544405, 544409
Abstract:
The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I or II:wherein the variables are as defined herein.
Process For Preparing Azabicyclic Compounds
US Patent:
8461352, Jun 11, 2013
Filed:
Mar 9, 2012
Appl. No.:
13/416157
Inventors:
Narendra Bhalchandra Ambhaikar - Hyderabad, IN
Brian Richard Bear - Oceanside CA, US
Lev T. D. Fanning - San Marcos CA, US
Robert Hughes - San Diego CA, US
Benjamin Littler - Carlsbad CA, US
Brian Richard Bear - Oceanside CA, US
Lev T. D. Fanning - San Marcos CA, US
Robert Hughes - San Diego CA, US
Benjamin Littler - Carlsbad CA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 487/08
US Classification:
548453
Abstract:
The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof.
Process For Preparing Modulators Of Cystic Fibrosis Transmembrane Conductance Regulator
US Patent:
2013007, Mar 21, 2013
Filed:
Nov 16, 2012
Appl. No.:
13/678840
Inventors:
Vertex Pharmaceuticals Incorporated - Cambridge MA, US
Robert Hughes - San Diego CA, US
Dennis James Hurley - San Marcos CA, US
Elaine Chungmin Lee - Cambridge MA, US
Benjamin Littler - Carlsbad CA, US
Mehdi Numa - San Diego CA, US
Stefanie Roeper - Medford MA, US
Urvi Sheth - San Diego CA, US
Robert Hughes - San Diego CA, US
Dennis James Hurley - San Marcos CA, US
Elaine Chungmin Lee - Cambridge MA, US
Benjamin Littler - Carlsbad CA, US
Mehdi Numa - San Diego CA, US
Stefanie Roeper - Medford MA, US
Urvi Sheth - San Diego CA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 487/08
US Classification:
546156
Abstract:
The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.
Process For Preparing Azabicyclic Compounds
US Patent:
8404865, Mar 26, 2013
Filed:
Sep 17, 2010
Appl. No.:
12/884925
Inventors:
Narendra Bhalchandra Ambhaikar - Hyderabad, IN
Brian Richard Bear - Oceanside CA, US
Lev T. D. Fanning - San Marcos CA, US
Robert Hughes - San Diego CA, US
Benjamin Littler - Carlsbad CA, US
Brian Richard Bear - Oceanside CA, US
Lev T. D. Fanning - San Marcos CA, US
Robert Hughes - San Diego CA, US
Benjamin Littler - Carlsbad CA, US
Assignee:
Vertex Pharmaceuticals - Cambridge MA
International Classification:
C07D 487/08
US Classification:
548453
Abstract:
The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof.
Processes For The Preparation Of Uracil Derivatives
US Patent:
2011009, Apr 28, 2011
Filed:
Nov 7, 2008
Appl. No.:
12/741819
Inventors:
Donald J. Gallagher - Hopkinton MA, US
Laszio R. Treiber - San Diego CA, US
Robert Michael Hughes - San Diego CA, US
Onorato Campopiano - Hayward CA, US
Peng Wang - Carlsbad CA, US
Yuxin Zhao - San Diego CA, US
Helen Chou - Wildwood MO, US
Michael Allen Ouellette - San Diego CA, US
Donald Nicholas Hettinger - Broomfield CO, US
Laszio R. Treiber - San Diego CA, US
Robert Michael Hughes - San Diego CA, US
Onorato Campopiano - Hayward CA, US
Peng Wang - Carlsbad CA, US
Yuxin Zhao - San Diego CA, US
Helen Chou - Wildwood MO, US
Michael Allen Ouellette - San Diego CA, US
Donald Nicholas Hettinger - Broomfield CO, US
International Classification:
C07D 239/54
US Classification:
544311
Abstract:
The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.