Inventors:
Robert Ashman - Iowa City IA, US
Petar Lenert - Iowa City IA, US
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
A01N 43/04, C12Q 1/68, C12P 19/34, C12N 15/63, C07H 21/02
US Classification:
514 44, 435 6, 435 911, 435455, 536 231
Abstract:
The present invention is drawn a new class of oligodeoxynucleotides (ODNs) that inhibit ODN-activation of Toll-like receptor (TLR)9. Particular 4-5 base extensions at the 5′ and of the previously described core inhibitory ODN sequence enhances their inhibitory activity against human cells expressing human TLR9. Methods of use also are provided.