Inventors:
Baldomero Olivera - Salt Lake City UT, US
J. McIntosh - Salt Lake City UT, US
Maren Watkins - Salt Lake City UT, US
James Garrett - Salt Lake City UT, US
Lourdes Cruz - Manila, PH
Michelle Grilley - Logan UT, US
Robert Schoenfeld - Sacramento CA, US
Craig Walker - Salt Lake City UT, US
Reshma Shetty - Salt Lake City UT, US
Robert Jones - Park City UT, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
A61K038/00, C07K005/00, C07K016/00, C07K007/00, C07K017/00, C07H021/04, C12N001/20, C12N015/00, C12N015/09, C12N015/63, C12N015/70, C12N015/74, C12N005/00, C12N005/02
US Classification:
530/324000, 514/012000, 536/023500, 435/320100, 435/252300, 435/325000
Abstract:
The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.