Inventors:
Robert Bookstein - La Jolla CA
William B. Isaacs - Glyndon MD
Assignee:
Canji, Inc. - San Diego CA
Johns Hopkins University - Baltimore MD
International Classification:
C12N 508, C12N 100, C12N 1563, C07H 2104
Abstract:
This invention provides a novel nucleic acid molecule encoding a prostate/colon tumor suppressor gene product. The means and methods for detecting mutations and/or loss of prostate/colon tumor suppressor gene are provided. Also included within the scope of this invention are methods of suppressing the neoplastic phenotype of cancer cells having a defect in the prostate/colon tumor suppressor gene product. The invention also includes the means and methods for treating the cancer by administering the prostate/colon tumor suppressor gene.