DR. ROBERT E SOBOL, M.D.
Osteopathic Medicine in Rancho Santa Fe, CA
License number
California G42623
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
7070 El Vuelo Del Este, Rancho Santa Fe, CA 92067
Phone
(619) 806-2000
(858) 756-0482 (Fax)
(858) 756-0482 (Fax)
Professional information
Compositions And Methods For Enhanced Tumor Cell Immunity In Vivo
US Patent:
6447769, Sep 10, 2002
Filed:
Mar 1, 2000
Appl. No.:
09/516737
Inventors:
Habib Fakhrai - La Jolla CA
Oliver Dorigo - San Diego CA
Robert E. Sobol - Rancho Santa Fe CA
Oliver Dorigo - San Diego CA
Robert E. Sobol - Rancho Santa Fe CA
Assignee:
Sidney Kimmel Cancer Center - San Diego CA
International Classification:
A01N 6300
US Classification:
424 932, 4353201, 435325, 435 914, 536 241
Abstract:
The invention provides a method of preventing or reducing the severity of a cancer in a subject by stimulating the subjects immune response against the cancer. The invention provides, for example, a method of stimulating an immune response in a subject by administering to the subject tumor cells that are substantially similar to the subjects cancer cells and that are genetically modified to reduce or inhibit the expression of one or more immunosuppressive agents. The invention also provides a method of preventing or reducing the severity of cancer in a subject by stimulating the subjects immune response against the cancer by administering to the subject tumor cells that are substantially similar to the subjects cancer cells and that are genetically modified to prevent the expression of an immunosuppressive agents and, in combination with the genetically modified tumor cells, an immunostimulatory agent. The invention further provides compositions useful for practicing the claimed methods.
Topical Administration Permitting Prolonged Exposure Of Target Cells To Therapeutic And Prophylactic Nucleic Acids
US Patent:
2007006, Mar 22, 2007
Filed:
Jan 20, 2006
Appl. No.:
11/336664
Inventors:
Peter Clarke - Sugar Land TX, US
Sunil Chada - Missouri City TX, US
Kerstin Menander - Bellaire TX, US
Robert Sobol - Rancho Santa Fe CA, US
Shuyuan Zhang - Sugar Land TX, US
Sunil Chada - Missouri City TX, US
Kerstin Menander - Bellaire TX, US
Robert Sobol - Rancho Santa Fe CA, US
Shuyuan Zhang - Sugar Land TX, US
International Classification:
A61K 48/00, A61K 9/68
US Classification:
514044000, 424440000, 424048000
Abstract:
Compositions and methods for preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include a nucleic acid comprised in a solid or semi-solid formation or in a transdermal or transcutaneous delivery device are disclosed. Also disclosed are compositions of a nucleic acid capable of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include an adhesive. Compositions of a nucleic acid capable of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include a nucleic acid uptake enhancer are also disclosed. Methods of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that involve these therapeutic compositions and devices are also disclosed.
Enhancing The Sensitivity Of Tumor Cells To Therapies
US Patent:
2004007, Apr 15, 2004
Filed:
Feb 25, 2003
Appl. No.:
10/374665
Inventors:
Robert Sobol - Rancho Santa Fe CA, US
Ruth Gjerset - San Diego CA, US
Ruth Gjerset - San Diego CA, US
International Classification:
A61K048/00
US Classification:
514/044000
Abstract:
A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.
Enhancing The Sensitivity Of Tumor Cells To Therapies
US Patent:
2002000, Jan 17, 2002
Filed:
Jan 26, 2001
Appl. No.:
09/769752
Inventors:
Robert Sobol - Rancho Santa Fe CA, US
Ruth Gjerset - San Diego CA, US
Ruth Gjerset - San Diego CA, US
International Classification:
A61K048/00
US Classification:
514/044000
Abstract:
A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.
Novel Clinical Trial Methods To Improve Drug Development For Disease Therapy And Prevention
US Patent:
2010027, Oct 28, 2010
Filed:
Mar 1, 2010
Appl. No.:
12/714973
Inventors:
Robert Sobol - Rancho Santa Fe CA, US
International Classification:
G06F 19/00
US Classification:
702 19
Abstract:
In one embodiment, a method for a multiplexed continuous biomarker clinical trial is disclosed that evaluates multiple drugs concurrently or subsequently against a continuously collected and enlarging control group with increasing statistical power.
Enhancing The Sensitivity Of Tumor Cells To Therapies
US Patent:
2002001, Jan 24, 2002
Filed:
Jan 10, 2001
Appl. No.:
09/758956
Inventors:
Robert Sobol - Rancho Santa Fe CA, US
Ruth Gjerset - San Diego CA, US
Ruth Gjerset - San Diego CA, US
International Classification:
A61K048/00
US Classification:
514/044000
Abstract:
A method for enhancing the effect of a cancer therapy by introducing wild-type therapy-sensitizing gene activity into tumor cells having mutant therapy-sensitizing gene activity and subjecting the tumor cells to a cancer therapy such as chemotherapy, radiotherapy, biological therapy including immunotherapy, cryotherapy and hyperthermia.
P53 Biomarkers
US Patent:
2011009, Apr 28, 2011
Filed:
Jan 26, 2009
Appl. No.:
12/863807
Inventors:
Robert E. Sobol - Rancho Santa Fe CA, US
Kerstin Menander - Bellaire TX, US
Kerstin Menander - Bellaire TX, US
Assignee:
P53 - Rancho Santa Fe CA
International Classification:
A61K 9/127, G01N 33/68, C12Q 1/68, C12Q 1/70, C40B 30/04, A61K 48/00, A61P 35/00, B82Y 5/00
US Classification:
424450, 435 792, 435 71, 436501, 435 6, 435 5, 506 9, 514 44 R, 424 936, 977773, 977800, 977906, 977916
Abstract:
The present invention relates to the identification of p biomarker profiles that predict response in patients with hyperproliferative disease such as cancer to a therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy.