Robert Douglas Walkup
Physician at Hwy 84, Shallowater, TX
License number
Colorado 54607
Issued Date
Nov 13, 2014
Renew Date
May 1, 2015
Expiration Date
Apr 30, 2017
Type
Physician
Address
Address
7117 Hwy 84, Shallowater, TX 79363
Professional information
Method Of Using Synthetic L-Se-Methylselenocysteine As A Nutriceutical And A Method Of Its Synthesis
US Patent:
2003008, May 1, 2003
Filed:
Nov 5, 2002
Appl. No.:
10/288024
Inventors:
Julian Spallholz - Lubbock TX, US
Ted Reid - Lubbock TX, US
Robert Walkup - shallowater TX, US
Ted Reid - Lubbock TX, US
Robert Walkup - shallowater TX, US
International Classification:
A61K031/198
US Classification:
514/561000
Abstract:
A synthesis of and use for L-Se-methylselenocysteine as a nutriceutical is described, based upon the knowledge that L-Se-methylselenocysteine is less toxic than L-selenomethionine towards normal cells. The synthesis proceeds by mixing N-(tert-butoxycarbonyl)-L-serine with a dialkyl diazodicarboxylate and at least one of a trialkylphosphine, triarylphosphine, and phosphite to form a first mixture that includes N-(tert-butoxycarbonyl)-L-serine -lactone. Methyl selenol or its salt is mixed with the N-(tert-butoxycarbonyl)-L-serine -lactone to form a second mixture that includes N-(tert-butoxycarbonyl)-Se-methylselenocysteine. The tert-butoxycarbonyl group is removed from the N-(tert-butoxycarbonyl)-Se-methylselenocysteine to form L-Se-methylselenocysteine. This synthesis significantly improves the manufacturability, manufacturing efficiency, and utility of this naturally occurring rare form of organic-selenium. L-Se-methylselenocysteine formed, for example, in this manner may be used as a nutriceutical for supplementation into the diets of humans or animals for various beneficial purposes, such as, for example, to prevent or reduce the risk of developing cancer.
Method Of Using Synthetic L-Se-Methylselenocysteine As A Nutriceutical And A Method Of Its Synthesis
US Patent:
2007008, Apr 19, 2007
Filed:
Oct 18, 2006
Appl. No.:
11/583630
Inventors:
Julian Spallholz - Lubbock TX, US
Ted Reid - Lubbock TX, US
Robert Walkup - Shallowater TX, US
Ted Reid - Lubbock TX, US
Robert Walkup - Shallowater TX, US
International Classification:
A61K 31/198
US Classification:
514561000
Abstract:
A synthesis of and use for L-Se-methylselenocysteine as a nutriceutical is described, based upon the knowledge that L-Se-methylselenocysteine is less toxic than L-selenomethionine towards normal cells. The synthesis proceeds by mixing N-(tert-butoxycarbonyl)-L-serine with a dialkyl diazodicarboxylate and at least one of a trialkylphosphine, triarylphosphine, and phosphite to form a first mixture that includes N-(tert-butoxycarbonyl)-L-serine β-lactone. Methyl selenol or its salt is mixed with the N-(tert-butoxycarbonyl)-L-serine β-lactone to form a second mixture that includes N-(tert-butoxycarbonyl)-Se-methylselenocysteine. The tert-butoxycarbonyl group is removed from the N-(tert-butoxycarbonyl)-Se-methylselenocysteine to form L-Se-methylselenocysteine. This synthesis significantly improves the manufacturability, manufacturing efficiency, and utility of this naturally occurring rare form of organic-selenium. L-Se-methylselenocysteine formed, for example, in this manner may be used as a nutriceutical for supplementation into the diets of humans or animals for various beneficial purposes, such as, for example, to prevent or reduce the risk of developing cancer.