Inventors:
John Nicholas Whitaker - Birmingham AL
Robert David Kachelhofer - Birmingham AL
Edwin Luther Bradley - Birmingham AL
Sheila Loughran Burgard - Lake Bluff IL
Beverly Ann Layton - Birmingham AL
Anthony Thomas Reder - Oak Park IL
Wendy Jean Morrision - Vancouver, CA
Guojun Zhao - Burnaby, CA
Donald Winston Paty - Vancouver, CA
Ligong Cao - Birmingham AL
Lori Coward - Birmingham AL
Patricia L. Jackson - Moody AL
Marion Kirk - Birmingham AL
Assignee:
UAB Research Foundation - Birmingham AL
International Classification:
G01N 3353, G01N 33566, G01N 33567, G01N 33536
Abstract:
The present invention provides a method of determining the status of a multiple sclerosis patient, i. e. , predicting the transition from a status of relapsing-remitting to a progressive phase of multiple sclerosis, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. The present invention also provides a method of determining the amount of lesions and total lesion area of a multiple sclerosis patient, comprising the step of measuring the amount of urinary p-cresol sulfate in the patient. Further provided is a method of monitoring myelination in a developing child, comprising the step of: measuring the amount of p-cresol sulfate in the urine of said child.