ROBERT C RAYNOR
Medical Practice at 21 St, Hollywood, FL

License number

Florida 536452

Issued Date

Aug 5, 2011

Effective Date

Jul 6, 2015

Expiration Date

Dec 1, 2014

Professional information

Ligand-Aminodextran-Marker Conjugates And Uses Thereof

US Patent:

6387622, May 14, 2002

Filed:

Oct 27, 1999

Appl. No.:

09/403919

Inventors:

Olavi Siiman - Davie FL
Alexander Burshteyn - Hialeah FL
Ravindra Mylvaganam - Hollywood FL
Robert Raynor - Cooper City FL
Patricia Roth - Pembroke Pines FL
Cecilia Smith - Miami FL
Julie Wilkinson - Weston FL

Assignee:

Coulter International Corp. - Miami FL

International Classification:

G01N 3368

US Classification:

435 6, 435 722, 435 723, 435 724, 435 725, 435 72, 436172, 436512, 436513, 436529, 436800, 436805, 5303911, 5303913, 5303915

Abstract:

Ligand-aminodextran-(phycobiliprotein or tandem dye) conjugates useful for detection of a desired target biological material by providing an enhanced fluorescent signal are described. Also described is a method for a single-measurement quantification of multiple populations of cells based upon the labeling of different pairs of cell populations, each pair containing mutually exclusive cell receptors which are expressed at substantially similar receptor densities with labeled ligands for each receptor. One cell population is labeled with a ligand capable of binding to a first cell surface receptor which ligand is directly conjugated to a fluorescent phycobiliprotein or tandem dye; and a second cell population is labeled with a ligand capable of binding to a second cell surface receptor, which ligand is cross-linked to an aminodextran to a fluorescent phycobiliprotein or tandem dye.

Stabilized Lyophilized Mammalian Cells And Method Of Making Same

US Patent:

5059518, Oct 22, 1991

Filed:

Oct 20, 1988

Appl. No.:

7/260260

Inventors:

Kenneth H. Kortright - Davie FL
Robert H. Raynor - Miramar FL
Stephen F. Healy - Miami FL

Assignee:

Coulter Corporation - Hialeah FL

International Classification:

A01N 102, C12Q 168, G01N 33569

US Classification:

435 6

Abstract:

A method of lyophilizing mammalian cells to produce preserved human cells, hybridoma cell lines, tissue cells, and control cells for immunoassays and other hematological measurements. Prior to freezing and lyophilizing, the prepared mammalian cell pellet is suspended in a solution of trehalose in an isotonic fluid prepared at a specified optimal concentration and incubated at room temperature for a designated time period. The lyophilized cells when rehydrated, retain their optimal physiological characteristics suitable for use as an analytical control and retain said characteristics after storage at 2. degree. -8. degree. C. for a period in excess of five (5) months.

Preparation Of Preserved, Non-Infectious Control Cell For Use In The Identification Of A Disease Through Blood Testing

US Patent:

5763204, Jun 9, 1998

Filed:

May 28, 1996

Appl. No.:

8/644993

Inventors:

John A. Maples - Davie FL
Robert H. Raynor - Miramar FL
Olavi Siiman - Davie FL
Melissa J. Stiglitz - North Miami Beach FL
Stephen F. Healy - Miami FL

Assignee:

Coulter Corporation - Miami FL

International Classification:

G01N 3353, G01N 33555, G01N 33567

US Classification:

435 724

Abstract:

Preparation of non-infectious control cells from normal, non-infectious, non-disease altered blood by depletion or augmentation of one or more cell types found in normal blood to reflect a specific disease state. The control cells so produced are preserved and thereafter reconstituted for use in immunological assays.

Method For Determination Of Leukocytes And Hemoglobin Concentration In Blood

US Patent:

5882933, Mar 16, 1999

Filed:

Jul 25, 1997

Appl. No.:

8/898000

Inventors:

Yi Li - Miami FL
Carole Young - Miami FL
Robert H. Raynor - Cooper City FL

Assignee:

Coulter International Corp. - Miami FL

International Classification:

G01N 3348, G01N 3372

US Classification:

436 63

Abstract:

A method is provided for differentiating leukocyte subpopulations, immunophenotyping of lymphocytes and counting white blood cells. The method preserves leukocyte morphology and surface markers without using fixatives. In addition, the method finds utility in determination of hemoglobin concentration without using cyanide. The stable hemoglobin chromogen formed is measured at approximately 540 nm.

Preserved, Non-Infectious Control Cell For Use In The Identification Of A Disease Through Blood Testing

US Patent:

5342754, Aug 30, 1994

Filed:

Sep 14, 1992

Appl. No.:

7/944678

Inventors:

John A. Maples - Davie FL
Robert H. Raynor - Miramar FL
Olavi Siiman - Davie FL
Melissa J. Stiglitz - North Miami Beach FL
Stephen F. Healy - Miami FL

Assignee:

Coulter Corporation - Miami FL

International Classification:

A01N 102, G01N 3100

US Classification:

435 2

Abstract:

The invention describes the preparation of non-infectious control cells from normal, non-infectious, non-disease altered blood by depletion or augmentation of one or more cell types found in normal blood to reflect a specific disease state. The control cells so produced are preserved and thereafter reconstituted for use in immunological assays.

Antibody-Aminodextran-Phycobiliprotein Conjugates

US Patent:

5891741, Apr 6, 1999

Filed:

May 16, 1997

Appl. No.:

8/857941

Inventors:

Olavi Siiman - Davie FL
Cecilia Smith - Miami FL
Patricia Roth - Pembroke Pines FL
Alexander Burshteyn - Hialeah FL
Robert Raynor - Cooper City FL

Assignee:

Coulter International Corp. - Miami FL

International Classification:

G01N 33548

US Classification:

436529

Abstract:

The present application discloses dextran crosslinked, antibody-phycobiliprotein conjugates containing up to twenty phycobiliprotein per dextran molecule which conjugates are able to achieve amplification of fluorescence intensity over direct antibody-phycobiliprotein labeled cells of two fold or greater.