DR. ROBERT BRUCE COHEN, PH.D.
Social Work at Waltham Woods Rd, Baltimore, MD

License number

Maryland 02388

Professional information

Psychologist At Robert B. Cohen, Ph.d., P.a.

Position:

Psychologist at Robert B Cohen, Ph.D., P.A., Psychologist at Robert Cohen, Ph.D., P.A.

Location:

Baltimore, Maryland Area

Industry:

Mental Health Care

Work:

Robert B Cohen, Ph.D., P.A. - Baltimore, Maryland and Ellicott City, Maryland since Sep 1989 - Psychologist Robert Cohen, Ph.D., P.A. since Sep 1989 - Psychologist

Education:

United States International University San Diego 1987
Doctor of Philosophy (Ph.D.), Clinical Psychology University of Rhode Island 1977
Bachelor of Arts (B.A.), Psychology Loyola College in Maryland 1981
M.A., Clinical Psychology

Skills:

Adolescents, Psychological Assessment, CBT, Family Therapy, Psychotherapy, Group Therapy, Mental Health, Life Transitions, Counseling Psychology, Clinical Supervision, Psychology, Interventions, Self-esteem, Post Traumatic Stress

Interests:

In April 1989, I began my own part-time private practice in Baltimore and in Ellicott City. In July 2003, I went into full-time practice where I have continued to provide psychological services including individual, family, marital, and couples therapy to a diversity of clients, including adults, adolescents, children and families. In addition, I have met the State of Maryland's requirements to provide parent coordination.

Dr. Robert B Cohen, Baltimore MD - PHD

Specialties:

Clinical Psychology

Address:

8813 Waltham Woods Rd STE 302, Baltimore 21234
(410) 665-4522 (Phone)

Languages:

English

Robert Bruce Cohen, Baltimore MD

Specialties:

Psychologist

Address:

8813 Waltham Woods Rd, Baltimore, MD 21234

Arrayed Multiple Ubiquitin Binding Domains As Linkage-Specific Polyubiquitin Affinity Reagents

US Patent:

2011025, Oct 13, 2011

Filed:

Jun 15, 2010

Appl. No.:

12/815740

Inventors:

Joshua J. Sims - Baltimore MD, US
Robert E. Cohen - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

G01N 33/566, C12N 9/00, C12N 1/21, C07K 14/00

US Classification:

435 71, 530350, 435183, 43525233, 436501

Abstract:

Linkage-specific polyubiquitin recognition is thought to make possible the diverse set of functional outcomes associated with ubiquitination. Thus far, mechanistic insight into this selectivity has been largely limited to single domains that preferentially bind to lysine 48-linked polyubiquitin (K48-polyUb) in isolation. A mechanism is proposed herein, linkage-specific avidity, in which multiple ubiquitin-binding domains are arranged in space so that simultaneous, high-affinity interactions are optimum with one polyUb linkage but unfavorable or impossible with other polyUb topologies and monoUb. The model used herein is human Rap80, which contains tandem ubiquitin interacting motifs (UIMs) that bind to K63-polyUb at DNA doublestrand breaks. The sequence between the Rap80 UIMs positions the domains for efficient avid binding across a single K63 linkage, thus defining selectivity. K48-specific avidity is also demonstrated in a different protein, ataxin-3. Using tandem UIMs, the general principles governing polyUb linkage selectivity and affinity in multivalent ubiquitin receptors are established.