Inventors:
Robert Alpern - Woodbridge CT, US
Jerry Buysse - Los Altos CA, US
Han Ting Chang - Livermore CA, US
Dominique Charmot - Campbell CA, US
Michael James Cope - Berkeley CA, US
John Fordtran - Dallas TX, US
Gerrit Klaerner - San Jose CA, US
Eric Connor - Los Gatos CA, US
Mingjun Liu - Campbell CA, US
Futian Liu - Mountain View CA, US
Jun Shao - Fremont CA, US
Assignee:
Relypsa, Inc. - Santa Clara CA
International Classification:
A61K 31/74, A61K 31/765, A61K 31/785, A61K 9/14, A61P 3/12, A61P 9/12, A61P 13/12
US Classification:
424 781, 424490, 424497, 514838, 514869, 514870, 514893
Abstract:
The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.