DR. ROBERT ALLEN SMITH, M.D.
Medical Practice in Jackson, MS

6124265, Sep 26, 2000

Jul 28, 1999

9/362253

Scott F. Timmons - San Antonio TX
Cheryl R. Blanchard - San Antonio TX
Robert A. Smith - Jackson MS

Keraplast Technologies, Ltd. - San Antonio TX

A61K 3800, A61K 970, A61K 3817, A61F 1300, A61L 1500

514 21

Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCl, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film.

2005016, Aug 4, 2005

Jan 31, 2005

11/047474

Mark Van Dyke - Fair Oaks Ranch TX, US
Cheryl Blanchard - Warsaw IN, US
Scott Timmons - San Antonio TX, US
Robert Smith - Jackson MS, US

A61F002/28, A61K009/70

424423000, 623016110

A keratin hydrogel-filled implantable prosthetic device. One device is a breast implant for augmenting or reconstructing a human breast including an envelope containing a keratin hydrogel. One keratin hydrogel is formed from a solid precursor which forms a keratin hydrogel upon addition of water. One source of keratin is human hair. In one method, an envelope suitable for implantation and a solid keratin hydrogel precursor are provided. The solid can be in fibrous or powder form. The solid precursor can be inserted into the envelope interior. A small incision near the breast can be made and the envelope inserted into the incision. After insertion, water can be injected into the envelope interior, preferably through the incision and through a self-sealing port in the envelope. In one method, the implant is provided as a kit, with the envelope and keratin hydrogel provided. The hydrogel can be injected into the envelope either before or after insertion into the breast area. One kit has a powdered, keratin hydrogel precursor disposed within the envelope interior, awaiting the addition of water, preferably after insertion of the implant into the body.

2008031, Dec 25, 2008

May 27, 2008

12/127694

Robert James Kelly - Christchurch, NZ
Gudmunder Fertram Sigurjonsson - Auckland, NZ
Clive Marsh - Christchurch, NZ
Robert Allen Smith - Jackson MS, US
Mohammad Azam Ali - Christchurch, NZ

A61K 9/70, A61K 38/17, A61P 19/00

424443, 514 12

A porous keratin construct for use in wound healing is disclosed. The porous keratin construct may be used standing alone or in combination with a synthetic foam backing layer. Either the porous keratin construct or the porous keratin construct and synthetic foam combination may be used in a wound therapy such as negative pressure wound therapy. An assembly for use in negative pressure wound therapy may comprise a porous keratin construct or porous keratin construct and synthetic foam combination, a wound drape to encapsulate the wound and the porous keratin construct or porous keratin construct and synthetic foam combination, and a vacuum source in fluid communication with the wound drape to apply a negative pressure to the area encapsulated by the wound drape

2001000, Jul 26, 2001

Dec 12, 2000

09/736957

Cheryl Blanchard - Warsaw IN, US
Scott Timmons - San Antonio TX, US
Robert Smith - Jackson MS, US

A61L015/00, A61K038/00

424/445000, 514/021000

A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

5358935, Oct 25, 1994

Nov 19, 1992

7/978768

Robert A. Smith - Jackson MS
Cheryl R. Blanchard - San Antonio TX
James Lankford - San Antonio TX

A61F 202, A61K 3712, C07K 302

514 21

The present invention is a new nonantigenic keratinous protein material that may be used as a number of purposes, including correction of soft tissue deficiencies and the creation of biomedical implants and implant coatings. The present invention also includes processes for using the nonantigenic keratinous protein material for soft tissue augmentation, creating implants, and the coating of biocompatible implants. The nonantigenic keratinous protein material can be formed by obtaining nonantigenic keratinous protein and processing it to a powder form. If hair from the recipient or a compatible doner is used, it is bleached and rinsed, then dried and chopped into about 0. 25 inch pieces. The keratinous protein is then homogenized in a solvent to a particular size generally in the range of about 0. 1 to about 500. mu. m.

2011019, Aug 11, 2011

May 4, 2006

11/920456

Chunyong Wu - Plymouth MN, US
Jun Li - Brookline MA, US
Douglas Wicks - Plymouth MN, US
Sarah Morgan - Hattiesburg MS, US
Robert Allen Smith - Jackson MS, US

C08H 1/06

530357

Keratin hydratable absorbents and films are fabricated with simple, repeatable processes. Freeze drying produces a material with instantaneous water absorption to over 20 times its weight in water. Films produced are flexible and uniform with water absorption 7-8 times the original weight.