DR. ROBERT ALAN STAR, M.D.
Osteopathic Medicine at Democracy Blvd, Bethesda, MD

6790636, Sep 14, 2004

Jun 13, 2001

09/881446

Robert A. Star - Bethesda MD
Hiroshi Murakami - Miyagi, JP
Lance A. Liotta - Bethesda MD
Kenneth R. Spring - Rockville MD

The United States of America as represented by the Department of Health and Human Services - Washington DC

G01N 3348

435 405, 435 71, 435 4052, 436164, 436172

Methods are disclosed for rapid and specific fluorescent staining of biological tissue samples that substantially preserve biological molecules such as mRNA. Methods for microdissecting tissue to obtain pure populations of cells or tissue structures based upon identifying and excising cells or tissue structures that are labeled with fluorescent specific binding agents are also included. A laser capture microdissection apparatus useful for identifying and isolating cells and tissue structures following rapid immunofluorescent staining is also disclosed.

6852842, Feb 8, 2005

Aug 26, 2002

10/229316

Martin W. Brechbiel - Annandale VA, US
Robert A. Star - Bethesda MD, US
Hisataka Kobayashi - Nishinomiya, JP

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

C07F005/00

534 15, 424 111, 424 91, 424 936

Small dendrimer-based MRI contrast agents are disclosed to accumulate in renal tubules. The accumulation enables visualization of renal structure and function, permitting assessment of structural and functional damage to the kidneys. In a disclosed embodiment, six, small dendrimer-based MRI contrast agents were synthesized, and their pharmacokinetics, whole body retention, and renal MRI images were evaluated in mice. Surprisingly, despite having unequal renal clearance properties, all of the dendrimer agents clearly visualized the renal anatomy and proximal straight tubules of the mice better than Gd-[DTPA]-dimeglumine. Dendrimer conjugate contrast agents prepared from PAMAM-G2D, DAB-G3D, and DAB-G2D dendrimers were excreted rapidly and may be acceptable for use in clinical applications.

2006010, May 11, 2006

Apr 22, 2005

11/113212

Seth Townsend - Skaneateles NY, US
Christopher Komanski - Orlando FL, US
Richard Boyer - Cooper City FL, US
Nathan Tedford - Somerville MA, US
Derek Fine - Baltimore MD, US
Robert Star - Bethesda MD, US

Renal Diagnostic Inc. - Cambridge MA

G05D 21/00

700266000

A real-time, non-invasive system and method for determining the level of an analyte of interest in the urine of a patient is disclosed. The system and method uses the measured level of an analyte of interest to detect the onset of acute renal failure (ARF) as early as possible to prevent that patient from developing the disease or mitigating the effects of the disease. The system and method may be used to monitor the recovery of a patient after an ARF diagnosis. Preferably, the analyte of interest is creatinine or urea. The system may be placed in the urine drain line of a patient between a Foley catheter or other urinary drain and a urine collection bag. The system makes substantially continuous measurements of the urine flow rate and the concentration of the analyte of interest to determine the mass excretion rate of the analyte so it may be monitored to detect if the patient experiences a delta change in the mass excretion rate of an analyte that is indicative of the onset of ARF or a change in renal function.

6951761, Oct 4, 2005

Aug 30, 2002

10/233193

Robert A. Star - Bethesda MD, US
Takehiko Miyaji - Rockville MD, US
Stephen M. Hewitt - Potomac MD, US
Lance A. Liotta - Bethesda MD, US

The United States of America as represented by the Department of Health and Human Services - Washington DC

G01N001/36, G01N001/00, G01N001/30, A01N001/02, C12Q001/00

436174, 436 8, 436 63, 435 11, 435 4, 435 5, 435 6, 435 71, 435 405, 435 911, 4353071, 435810

This disclosure relates to CryoArrays, which permit the analysis of samples (such as protein, nucleic acid, virus, or cell samples) in arrays that are prepared at low temperatures. Because CryoArrays are constructed as a block of substantially columnar samples, the block can be sliced to provide a plurality of identical or substantially identical individual arrays. The individual arrays can be used for parallel analysis of the same array feature set, for instance with different probes or under different conditions. Also provided are methods of making CryoArrays, devices for making CryoArrays, and kits.

2005004, Feb 24, 2005

Jul 30, 2004

10/903324

Robert Star - Bethesda MD, US
Hiroshi Murakami - Miyagi, JP
Lance Liotta - Bethesda MD, US
Kenneth Spring - Rockville MD, US

C12Q001/68, G01N033/53, G01N033/567

435007200, 435006000

Methods are disclosed for rapid and specific fluorescent staining of biological tissue samples that substantially preserve biological molecules such as mRNA. Methods for microdissecting tissue to obtain pure populations of cells or tissue structures based upon identifying and excising cells or tissue structures that are labeled with fluorescent specific binding agents are also included. A laser capture microdissection apparatus useful for identifying and isolating cells and tissue structures following rapid immunofluorescent staining is also disclosed.