DR. ROBERT AARON LEVINE, MD
Osteopathic Medicine at Winthrop Rd, Guilford, CT

5759794, Jun 2, 1998

Dec 23, 1996

8/771506

Robert A. Levine - Guilford CT
Stephen C. Wardlaw - Old Saybrook CT
Rodolfo R. Rodriguez - Owings Mills MD

Becton Dickins & Co. - Franklin Lakes NJ

G01N 33543, G01N 33558

435 724

A patient's health may be diagnosed by centrifuging blood samples in a transparent tube, which tube contains one or more bodies or groups of bodies such as floats, inserts, liposomes, or plastic beads of different densities. Each density-defined body carries analyte-capture binding materials such as antigens or antibodies, which are specific to an epitope, or other specific high affinity binding site on a target analyte which target analyte may be in the blood or other sample being tested; and the level of which analyte is indicative of the patient's health. At least one labeled binding material which is also specific to an epitope, or other specific high affinity binding site on the target analyte is added to the sample so as to form labeled binding material/analyte/body complexes in the sample. Upon centrifugation, the complexes will settle out in different areas in the tube according to the respective density of the body or bodies; and the degree of label emission of the complex layers can enable qualitative and/or quantitative analyses of the sample to be made. Unbound labeled binding materials will be separated from the complexed layers by the washing action of ascending or descending components of the sample during the centrifugation step.

5251474, Oct 12, 1993

Jan 16, 1992

7/822321

Stephen C. Wardlaw - Old Saybrook CT
Robert A. Levine - Guilford CT

G01N 3348, B04B 504, B01D 2126, B01D 17038

73 6141

Centrifuged material layer measurements are made in an evacuated glass or clear plastic tube which contains a float. When possibly contaminated materials, such as blood, are being tested the use of the evacuated tube allows the measurements to be made without the technician being exposed to the blood. The tubes are large enough to hold approximately one ml of blood, and are filled with an inert gas at low pressure. The floats are formed with a through passage into which the cell bands to be expanded will settle during centrifugation.

5171528, Dec 15, 1992

Aug 5, 1991

7/740289

Stephen C. Wardlaw - Branford CT
Robert A. Levine - Guilford CT

G01N 2178, G01N 3372

422 56

The specification discloses a fecal occult blood test device capable of determining whether the blood found during the test originated in the upper or lower gastrointestinal track. A fecal sample is applied to a test medium charged to be differentially attractive to blood components originating in the upper and lower gastrointestinal track respectively. A solvent is applied to the test specimen to cause differential migration of the blood components and an indicator is then applied to indicate the presence of the blood components, if any.

4273741, Jun 16, 1981

Jan 7, 1980

6/110437

Robert A. Levine - Guilford CT

G01N 102, G01N 3352, G01N 3372

422 56

The device is usable by a patient to self-obtain a relatively constant volume stool sample for use in testing for gastro-intestinal bleeding. The device is a multi-layered pad which can be dispensed by a physician or the like to the patient and which the patient can use in privacy. The device is used in the same manner as toilet tissue to obtain the stool sample after defecation. Excess stool sample is discarded in the toilet and an appropriate amount of the stool sample is retained on the pad. The pad is then sealed and returned to the physician or testing laboratory hermetically sealed. The seal is broken, the test is performed, and then the pad is resealed hermetically and discarded.

4940668, Jul 10, 1990

Sep 18, 1987

7/098370

Stephen C. Wardlaw - Branford CT
Robert A. Levine - Guilford CT
Rodolfo R. Rodriguez - Randolph NJ
Michael R. Loken - Los Altos CA

Becton Dickinson and Company - Parsippany NJ

G01N 100

436174

In order to produce a more well defined interface between adjacent cell layers in a centrifuged sample of anticoagulated whole blood, a material which will bond one group of cells together is added to the blood sample prior to centrifugation. The bonding material must produce a high strength bond between one group of cells, but not effect the other cell types. The material is added prior to centrifugation of the blood sample.

4746238, May 24, 1988

Nov 3, 1986

6/925979

Robert A. Levine - Guilford CT

B05C 2100

401196

The stick swab has one or more compliant heads adapted for cleaning body orifices such as ear canals. The head or heads are formed with a contoured outer surface to aid in gripping and removing material or debris from the body orifices. The contours preferably take the form of a helical augur whereby material will be withdrawn from the orifice merely by appropriately rotating the swab about its axis.

5321975, Jun 21, 1994

Oct 4, 1991

7/770875

Robert A. Levine - Guilford CT
Stephen C. Wardlaw - Old Saybrook CT

G01N 3348, A61B 514

73 6171

Erythrocytes exist in vivo in a continuous cell subset gradient of density, with the youngest cells being the lightest. A blood sample is centrifuged in a transparent tube containing plastic beads which are selected to include groups of beads wherein each group has a different sharply defined specific gravity, and which are distributed within the range of red cell densities. The beads form spaced well-defined bands in the erythrocyte layer, which bands form boundaries between the different cell subset layers. Measurements of the lengths of the different cell subset layers are then made to quantify the red cell subsets in the patient's blood.

4779976, Oct 25, 1988

Aug 31, 1987

7/091380

Robert A. Levine - Guilford CT
Stephen C. Wardlaw - Old Saybrook CT

G01N 3316

356 39

Blood samples of animals are taken and analyzed for several different cell parameters. The analysis is made by centrifuging an anticoagulated blood sample in a capillary tube containing a float which physically elongates certain of the component cell layers in the sample. The instrument in which the parameter measurements are made is computerized and can be preset to take measurements of the blood of any one of several different types of animals whose respective blood cells have different packing coefficients.

4170995, Oct 16, 1979

Nov 21, 1977

5/853321

Robert A. Levine - Guilford CT
Stephen C. Wardlaw - Branford CT

A61B 1700

128346

A holder for clamping in place a catheter or other hollow tube, such as a urinary catheter tube, a nasogastric tube or intravenous tube on a patient's body, which holder includes a pliant adhesive-bearing base which is adhered to the patient's skin. The holder is adjustable so as to be capable of holding the catheter tube against rotary and longitudinal movement, and also be capable of partially or completely closing the bore of the catheter tube by deforming the tube wall.