ROBERT A MASTICO
Broker in Braintree, MA
License number
Massachusetts 44640
Issued Date
Mar 1, 1965
Expiration Date
Jun 29, 2004
Type
Broker
Address
Address
Braintree, MA 02184
Professional information
Rna Bacteriophage-Based Delivery System
US Patent:
6159728, Dec 12, 2000
Filed:
Jan 24, 1995
Appl. No.:
8/360694
Inventors:
Peter George Stockley - Ilkley, GB
Robert Allan Mastico - Braintree MA
Robert Allan Mastico - Braintree MA
Assignee:
BTG International Limited - London
International Classification:
A01N 6300, C12N 700, C12N 701
US Classification:
4353201
Abstract:
A delivery system, especially for delivery to targeted sites in the human or animal body, comprises capsids of the coat protein amino acid sequence of phage MS-2 or related phage, or a modification thereof which retains capsid-forming capability, and at least some of the capsids enclosing a moiety foreign to the genome of MS-2 or related phage.
Antigen-Presenting Capsid With Fusion Ms2-Coat Protein
US Patent:
5534257, Jul 9, 1996
Filed:
Nov 8, 1993
Appl. No.:
8/090148
Inventors:
Robert A. Mastico - Braintree MA
Peter G. Stockley - Ilkley, GB2
Simon J. Talbot - Street, GB2
Peter G. Stockley - Ilkley, GB2
Simon J. Talbot - Street, GB2
Assignee:
British Technology Group Limited
International Classification:
A61K 39116, A61K 3912, C07K 14195, C12N 701
US Classification:
4241921
Abstract:
A chimaeric protein, suitable for incorporation in a vaccine and capable of forming parts of a capsid assembly, comprises the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain capsid-forming capability, which amino acid sequence has been modified by insertion of a foreign epitope in the region corresponding to a protuberant protein hairpin in the capsid assembly as shown in the crystal structure of the intact phage.
Apparatus For Measuring Impedance To Determine A Property Of A Material
US Patent:
5450015, Sep 12, 1995
Filed:
Feb 24, 1994
Appl. No.:
8/201514
Inventors:
Robert A. Mastico - Braintree MA
Robert R. Moline - Braintree MA
Robert R. Moline - Braintree MA
Assignee:
Forte Technology, Inc. - Norwood MA
International Classification:
G01N 2722, G01R 2726
US Classification:
324665
Abstract:
An impedance measurement system including a series circuit having a reference impedance leg and a measurement leg, the measurement leg including first and second spaced apart electrodes defining a region for receiving a sample of material to be tested; an oscillator circuit connected in parallel with the series circuit and providing a reference voltage and a signal voltage proportioned to the impedance of the measurement leg; and a detector circuit producing an output voltage proportional to changes between the reference voltage and the signal voltage.
Capsid Forming And Cystein Modified Chimaeric Ms2-Coat Protein
US Patent:
5698424, Dec 16, 1997
Filed:
Jan 3, 1995
Appl. No.:
8/167982
Inventors:
Robert Allan Mastico - Braintree MA
Peter George Stockley - Ilkley, GB2
Peter George Stockley - Ilkley, GB2
Assignee:
British Technology Group Ltd.
International Classification:
C12N 1511, A61K 3576
US Classification:
4351723
Abstract:
A chimaeric protein is provided, capable of forming part of a capsid assembly and comprising the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain the capability of forming a capsid assembly, which amino acid sequence has been modified by removal of the cysteine residues present externally of the N-terminal protruberant. beta. -hairpin of the coat protein and insertion of a cysteine residue within the region corresponding to the N-terminal protruberant. beta. -hairpin.