Inventors:
Tobias Schroder - Somerville MA, US
Marcos F. Vidal Melo - Newton MA, US
Guido Musch - Somerville MA, US
Robert Scott Harris - Wayland MA, US
Jose G. Venegas - Swampscott MA, US
Tilo Winkler - Brookline MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61B 6/00
Abstract:
An input function indicative of a time-activity curve in pulmonary arterial plasma is produced from a series of PET image frames in lieu of manual blood sampling. Two manually acquired blood samples are input along with pixel values of a blood pool region of interest (ROI) in the PET image frames into a two-parameter model of the ROI's time-activity curve. In an iterative process the model converges to accurately indicate the amount of F-FDG tracer in the arterial blood. Pulmonary uptake of the tracer is assessed with the PET image frames and the calculated input function.