ROBERT A GATENBY
Medical Practice at Leith Walk, Tampa, FL
License number
Florida 100645
Issued Date
Dec 20, 2007
Effective Date
Dec 20, 2007
Expiration Date
Jan 31, 2018
Category
Health Care
Type
Medical Doctor
Address
Address
15203 Leith Walk Ln, Tampa, FL 33618
Phone
(813) 745-5284
Professional information
Physician At Moffitt Cancer Center
Position:
physician at Moffitt Cancer Center, radiologist at H. Lee Moffitt Cancer Center and Research Institute
Location:
Tampa/St. Petersburg, Florida Area
Industry:
Hospital & Health Care
Work:
Moffitt Cancer Center
-
physician
H. Lee Moffitt Cancer Center and Research Institute
since 2008
-
radiologist
Robert A Gatenby, Tucson AZ
Specialties:
Radiologist
Address:
1501 N Campbell Ave, Tucson, AZ 85724
12902 Magnolia, Tampa, FL 33612
12902 Magnolia, Tampa, FL 33612
Education:
University of Pennsylvania, Perelman School of Medicine - Doctor of Medicine
Board certifications:
American Board of Radiology Certification in Diagnostic Radiology (Radiology)
Method Of Increasing Intratumoral Phe And Reducing Acid-Mediated Invasion
US Patent:
2012027, Nov 1, 2012
Filed:
May 24, 2012
Appl. No.:
13/479638
Inventors:
Robert J. Gillies - Tampa FL, US
David L. Morse - Tampa FL, US
Ariosto Siqueira Silva - Tampa FL, US
Arig A. Ibrahim Hashim - Tampa FL, US
Robert A. Gatenby - Tampa FL, US
Gary Martinez - Temple Terrace FL, US
David L. Morse - Tampa FL, US
Ariosto Siqueira Silva - Tampa FL, US
Arig A. Ibrahim Hashim - Tampa FL, US
Robert A. Gatenby - Tampa FL, US
Gary Martinez - Temple Terrace FL, US
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc. - Tampa
International Classification:
A61K 31/185, A61K 31/4172, A61P 35/04, A61K 31/14, A61P 35/00, A61K 31/495, A61K 31/198
US Classification:
51425212, 514400, 514578, 514564, 514642
Abstract:
A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.