Inventors:
Senlin Li - San Antonio TX, US
Robert A. Clark - San Antonio TX, US
Assignee:
The Board of Regents of the University of Texas - Austin TX
International Classification:
C07H 21/04, C12N 15/63, C12N 15/00, C12N 5/00, C12Q 1/68
US Classification:
536 241, 435455, 4353201, 435325
Abstract:
The present invention provides an isolated nucleic acid comprising a promoter operably linked to a nucleic acid encoding a peptide or protein and/or an RNA (e. g. , antisense or ribozyme), wherein the promoter comprises elements that can include, but are not limited to, a) a myeloid specific promoter element comprising a core sequence GAGGAA; b) a myeloid specific promoter element comprising a core sequence AAGGAGAAG; c) a myeloid specific promoter element comprising a core sequence TTTCCAAA; d) a myeloid specific promoter element comprising a core sequence TGTGGTTGC; e) a myeloid specific promoter element comprising a core sequence TGAGTCA; f) a myeloid associated promoter element comprising a core sequence CCGCCC; and g) any combination of (a), (b), (c), (d), (e) and/or (f), any combination of multiples of (a), (b), (c), (d), (e) and/or (f), in any order and/or in any orientation (forward or reverse).