Inventors:
Petr Pancoska - Pittsburgh PA, US
Robert A. Branch - Pittsburgh PA, US
Patrick M. Dudas - Edinburg PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
G06F 19/00
Abstract:
System(s) and method(s) for analysis and design of genome sequences are provided. A graph representation of a genome sequence facilitates generation of a thermodynamic based quantity, e.g., an entropy-based and enthalpy-based thermodynamic tolerance [τ], which in turn affords estimation of a gene sequence potential function that depends at least upon structural and functional properties of the gene sequence. The gene sequence potential (Φ) is determined, at least in part, via a generalized Schrödinger equation for the thermodynamic tolerance. Gene sequence potential and thermodynamic tolerance [τ], and derived quantities, like thermodynamic tolerance profile and generalized homology, provide an analytic instrument for characterization of natural and synthetic gene sequences, and in conjunction with graph-based algorithms embodies a tool for design of genome sequences with predetermined properties.