Inventors:
Robert A. Baiocchi - Columbus OH, US
Michael A. Caligiuri - Columbus OH, US
Anne M. Van Buskirk - Westerville OH, US
Assignee:
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH
International Classification:
A61K 39/395, C12Q 1/68, C12Q 1/02
US Classification:
4241331, 4241581, 4241721, 435 6, 435 29
Abstract:
The disclosure relates to methods to prevent, treat, or slow the progression viral-associated lymphoproliferative disorders, EBV-associated lymphoproliferative disorders, and post-transplant lymphoproliferative disorders. In the methods, a TGF-β antagonist, e.g., an anti-TGF-β antibody is administered to a subject. Methods for treating viral-associated lymphoproliferative disorders and for enhancing T-cell responsiveness to a viral-associated lymphoproliferative disorder by administering a TGF-β antagonist are also described.