RISHI P SINGH, MD
Medical Practice at Euclid Ave, Cleveland, OH

2011027, Nov 10, 2011

May 13, 2011

13/107582

RISHI P. SINGH - SHAKER HEIGHTS OH, US
WILLIAM G. LIONETTA - HARWICH PORT MA, US
MARC E. LAROSEE - WILMINGTON MA, US
GEORGE R. WATCHKO - STONEHAM MA, US
JOHN WRISLEY - LONDONDERRY NH, US
STEVEN L. THORNTON - WINDHAM NH, US
LAWRENCE R. MOSCHINI - CARLISLE MA, US
DAVID P. HILL - MEDFIELD MA, US
MICHAEL H. BUNYAN - CHELMSFORD MA, US
CHI HANG WU - QUINCY MA, US

A61F 9/00, A61N 1/30

604 20

A contact electrode assembly for delivering at least one therapeutic agent into ocular tissue of a subject includes a flexible dielectric layer, a first electrode portion, and a second electrode portion. The flexible dielectric includes oppositely disposed first and second surfaces. The first electrode portion is disposed on the first surface of the dielectric layer. The second electrode portion is disposed on a portion of the second surface of the dielectric layer. The second electrode portion includes an interdigitated electrode having a first comb-shaped portion defining a first plurality of fingers and a second comb-shaped portion defining a second plurality of fingers. Each of the first electrode portion, the first comb-shaped portion, and the second comb-shaped portion is electrically connectable to a signal source.

8311624, Nov 13, 2012

Sep 25, 2009

12/567653

Rishi P. Singh - Shaker Heights OH, US
Vadim F. Lvovich - Cleveland Heights OH, US
Brian L. Davis - Moreland Hills OH, US

The Cleveland Clinic Foundation - Cleveland OH

A61N 1/30, A61M 35/00

604 20, 604289, 604294, 604295, 604300

An apparatus for delivering at least one therapeutic agent to an ocular tissue of a subject includes at least one electrode, a medicament layer including the at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. The at least one electrode has oppositely disposed, dome-shaped first and second major surfaces. The first major surface is curved such that the first major surface substantially conforms to a contour of the ocular tissue when placed in contact with the ocular tissue. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source provides a signal having certain characteristics and is electrically connected to the at least one electrode. The certain characteristics comprise at least one orienting frequency and at least one motivating frequency sufficient to motivate the at least one therapeutic agent into the ocular tissue.