RICHARD WILLIAM CONNORS
Pilots at Belle Ln, Harleysville, PA
License number
Pennsylvania A2957097
Issued Date
Jun 2015
Expiration Date
Jun 2017
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
424 Belle Ln, Harleysville, PA 19438
Professional information
3-Phenyl Analogs Of Toxoflavine As Kinase Inhibitors
US Patent:
2005023, Oct 27, 2005
Filed:
Jul 8, 2003
Appl. No.:
10/520768
Inventors:
Jean LaCrampe - Le Mesnil-Esnard, FR
Richard Connors - Harleysville PA, US
Chih Ho - Spring Howie PA, US
Alan Ricardson - Buckingham, GB
Eddy Freyne - Rumst, BE
Peter Jacobus Buijnsters - Breda, NL
Annette Bakker - Borgerhout, BE
Richard Connors - Harleysville PA, US
Chih Ho - Spring Howie PA, US
Alan Ricardson - Buckingham, GB
Eddy Freyne - Rumst, BE
Peter Jacobus Buijnsters - Breda, NL
Annette Bakker - Borgerhout, BE
International Classification:
A61K031/53, C07D487/02
US Classification:
514242000, 544184000
Abstract:
The present invention concerns the compounds of formula
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereo-chemically isomeric forms thereof, wherein n represents an integer being 0, 1 or 2; m represents an integer being 0 or 1; R represents Calkyl; R represents Calkyl; Rrepresents Calkyl; or Rand Rtaken together with the carbon atom to which they are attached form a Ccycloalkyl or Hetwherein said Ccycloalkyl or Heteach independently may optionally be substituted with Calkyloxycarbonyl; Rrepresents halo or Calkyloxy; Rrepresents Calkyloxycarbonyl, —O-(mono- or di(Calkyl)aminosulfonyl), Calkyl substituted with one or where possible more substituent being selected from Hetor NRR, Calkyloxy substituted with one or where possible more substituents being selected from amino, Hetor NRR; Rand Rare each independently selected from hydrogen, Calkyl, CalkyloxyCalkyl, -Hetor Calkyl substituted with one or where possible more substituents being selected from hydroxy, or Het; Rand Rare each independently selected from hydrogen, Calkyl, -Hetor mono- or di(Calkyl)aminosulphonyl; Hetrepresents a heterocycle selected from piperidinyl, or piperazinyl wherein said monocyclic heterocycles each independently may optionally be substituted with one, or where possible two or three substituents each independently selected from hydroxy, aminosulfonyl, amino, mono- or di(Calkyl)aminosulfonyl, hydroxyCalkyloxyCalkyl or Calkyloxy; Hetrepresents a heterocycle selected from morpholinyl, piperidinyl or piperazinyl wherein said monocyclic heterocycles each independently may optionally be substituted with one, or where possible two or three substituents each independently selected from Calkyl, Calkyloxycarbonyl or mono- or di(Calkyl)aminosulfonyl; Hetrepresents a heterocycle selected from pyridinyl or piperidinyl wherein said monocyclic heterocycles each independently may optionally be substituted with one, or where possible two or three substituents each independently selected from aminosulfonyl, or mono- or di(Calkyl)aminosulfonyl; Hetrepresents piperidinyl.
Immobilized N-Substituted Tricyclic 3-Aminopyrazoles For The Identification Of Biomolecular Targets
US Patent:
2005013, Jun 16, 2005
Filed:
Nov 10, 2004
Appl. No.:
10/986500
Inventors:
Chih Ho - Lansdale PA, US
Robert Galemmo - Paoli PA, US
Dana Johnson - Upper Black Eddy PA, US
Jay Mei - North Wales PA, US
Stanley Belkowski - Norristown PA, US
Richard Connors - Harleysville PA, US
Robert Galemmo - Paoli PA, US
Dana Johnson - Upper Black Eddy PA, US
Jay Mei - North Wales PA, US
Stanley Belkowski - Norristown PA, US
Richard Connors - Harleysville PA, US
International Classification:
A61K031/7056, A61K031/427, A61K031/422, A61K031/4162, C07H017/00, C07D417/02, C07D413/02
US Classification:
514023000, 514365000, 514374000, 514406000, 536017400, 548181000, 548215000
Abstract:
The present invention relates to immobilized N-substituted tricyclic 3-aminopyrazole compounds of Formula 1 as tools for the identification of bimolecular targets in cells of therapeutic significance, profiling the selectivity of compounds, prediction of possible related toxicities and exploration of mechanisms of action in biological systems for therapeutic indications related to compounds. These agents can be used to identify biomolecules with the potential to interact with the immobilized reagent. The identified biomolecule may be then be used as a therapeutic target, serve as a marker of drug action, or alternatively describe an untoward or toxic potential of the immobilized agent.
Biomarkers For Assessing Response To C-Met Treatment
US Patent:
2011015, Jun 23, 2011
Filed:
Dec 17, 2010
Appl. No.:
12/972085
Inventors:
Richard W. Connors - Harleysville PA, US
Assignee:
Janssen Pharmaceutica N.V. - Beerse
International Classification:
C12Q 1/68, C07K 14/475, C07K 14/46, C07K 14/705, C12N 9/64, C12Q 1/37, C12Q 1/02
US Classification:
435 613, 530399, 530395, 435226, 435 23, 435 29
Abstract:
Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, thus indicating that these biomarkers are involved in c-met activity.
Biomarkers For Assessing Response To C-Met Treatment
US Patent:
2008009, Apr 24, 2008
Filed:
Aug 29, 2007
Appl. No.:
11/846684
Inventors:
Richard CONNORS - Harleysville PA, US
International Classification:
C12Q 1/68, C07H 21/00, C07K 2/00, C12Q 1/02
US Classification:
435006000, 435029000, 530300000, 536023100
Abstract:
Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, thus indicating that these biomarkers are involved in c-met activity.
3-Furanyl Analogs Of Toxoflavine As Kinase Inhibitors
US Patent:
7241763, Jul 10, 2007
Filed:
Jul 8, 2003
Appl. No.:
10/520641
Inventors:
Jean Fernand Armand LaCrampe - Le Mesnil-Esnard, FR
Richard William Connors - Harleysville PA, US
Chih Yung Ho - Drinnon Way PA, US
Alan Richardson - Buckingham, GB
Eddy Jean Edgard Freyne - Rumst, BE
Peter Jacobus Johannes Buijnsters - JX Breda, NL
Annette Cornelia Bakker - Borgerhout, BE
Richard William Connors - Harleysville PA, US
Chih Yung Ho - Drinnon Way PA, US
Alan Richardson - Buckingham, GB
Eddy Jean Edgard Freyne - Rumst, BE
Peter Jacobus Johannes Buijnsters - JX Breda, NL
Annette Cornelia Bakker - Borgerhout, BE
Assignee:
Janssen Pharmaceutica N.V.
International Classification:
C07D 407/04, C07D 487/04, A61K 31/53, A61P 35/00, A61P 19/02
US Classification:
514243, 544184
Abstract:
The present invention concerns the compounds of formula.
Triazolopyridazine Compounds
US Patent:
8173654, May 8, 2012
Filed:
Aug 7, 2008
Appl. No.:
12/187524
Inventors:
Tianbao Lu - Churchville PA, US
Richard Alexander - Newark DE, US
Richard W. Connors - Harleysville PA, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Heather Rae Hufnagel - Glenmoore PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Ehab Khalil - West Chester PA, US
Kristi A. Leonard - Flourtown PA, US
Thomas P. Markotan - Morgantown PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Jeremy M. Travins - Downingtown PA, US
Robert W. Tuman - Chalfont PA, US
Richard Alexander - Newark DE, US
Richard W. Connors - Harleysville PA, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Heather Rae Hufnagel - Glenmoore PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Ehab Khalil - West Chester PA, US
Kristi A. Leonard - Flourtown PA, US
Thomas P. Markotan - Morgantown PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Jeremy M. Travins - Downingtown PA, US
Robert W. Tuman - Chalfont PA, US
Assignee:
Janssen Pharmaceutica N.V. - Beerse
International Classification:
A61K 31/4985, C07D 487/04, A61P 3/10, A61P 17/06, A61P 25/18, A61P 19/02, A61P 9/10, A61P 9/00, A61P 35/00
US Classification:
514248, 544236
Abstract:
The invention is directed to triazolopyridazine compounds of Formula I:.
Triazolopyridazines As Kinase Modulators
US Patent:
8030305, Oct 4, 2011
Filed:
Dec 18, 2006
Appl. No.:
11/612020
Inventors:
Tianbao Lu - Churchville PA, US
Richard Alexander - Newark DE, US
Richard W. Connors - Harleysville PA, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Heather Rae Hufnagel - Glenmoore PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Ehab Khalil - West Chester PA, US
Kristi A. Leonard - Flourtown PA, US
Thomas P. Markotan - Morgantown PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Jeremy M. Travins - Downingtown PA, US
Robert W. Tuman - Chalfont PA, US
Richard Alexander - Newark DE, US
Richard W. Connors - Harleysville PA, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Heather Rae Hufnagel - Glenmoore PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Ehab Khalil - West Chester PA, US
Kristi A. Leonard - Flourtown PA, US
Thomas P. Markotan - Morgantown PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Jeremy M. Travins - Downingtown PA, US
Robert W. Tuman - Chalfont PA, US
Assignee:
Janssen Pharmaceutica N.V.
International Classification:
C07D 487/04, A61K 31/5025, A61P 35/00
US Classification:
514248, 544236
Abstract:
The invention is directed to triazolopyridazine compounds of Formula I:.
Acylhydrazones As Kinase Modulators
US Patent:
7662824, Feb 16, 2010
Filed:
Mar 16, 2006
Appl. No.:
11/377077
Inventors:
Kristi Leonard - West Chester PA, US
Tianbao Lu - Churchville PA, US
Robert W. Tuman - Chalfont PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Richard W. Connors - Harleysville PA, US
Richard S. Alexander - Newark DE, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Thomas P. Markotan - Morgantown PA, US
Tianbao Lu - Churchville PA, US
Robert W. Tuman - Chalfont PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Richard W. Connors - Harleysville PA, US
Richard S. Alexander - Newark DE, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Thomas P. Markotan - Morgantown PA, US
Assignee:
Janssen Pharmaceutica NV - Beerse
International Classification:
A61K 31/496, A61K 31/404, C07D 405/14, C07D 405/12, C07D 407/14
US Classification:
51425409, 514414, 514418, 514422, 514323, 514469, 514416, 544373, 544144, 546201, 548454, 548483, 548518, 548525, 548490, 549462
Abstract:
The invention is directed to acylhydrazones compounds of Formula I:.
Triazolopyrimidine Derivatives
US Patent:
7563781, Jul 21, 2009
Filed:
Jan 11, 2006
Appl. No.:
11/329642
Inventors:
Donald W. Ludovici - Quakertown PA, US
Richard W. Connors - Harleysville PA, US
Steven J. Coats - Quakertown PA, US
Li Liu - Doylestown PA, US
Bart L. De Corte - Southampton PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Mark J. Schulz - Skippack PA, US
Richard W. Connors - Harleysville PA, US
Steven J. Coats - Quakertown PA, US
Li Liu - Doylestown PA, US
Bart L. De Corte - Southampton PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Mark J. Schulz - Skippack PA, US
Assignee:
Janssen Pharmaceutica NV
International Classification:
C07D 487/04, C07F 9/40, A61K 31/5355, A61K 31/519, C07D 239/30, A61P 35/00, G01N 33/53, C07H 21/04, C12P 21/06, C12N 5/06, C07K 16/40, C12N 9/12
US Classification:
514 81, 5142611, 5142342, 51425212, 544118, 544244, 544254, 544326, 544329, 435 71, 435 691, 435194, 435348, 536 232, 5303911
Abstract:
The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.