RICHARD T WALKER
Medical Practice at Psge Way, Largo, FL

License number

Florida 17190

Issued Date

Mar 1, 1985

Effective Date

Dec 28, 2016

Expiration Date

Dec 1, 2018

Professional information

Method Of Diagnosing Pituitary Dependent Growth Hormone Deficiency

US Patent:

5811074, Sep 22, 1998

Filed:

Sep 30, 1996

Appl. No.:

8/722294

Inventors:

Barry B. Bercu - Tampa FL
Richard F. Walker - Indian Rocks Beach FL

Assignee:

University of South Florida - Tampa FL

International Classification:

G01N 3350, A61K 3804, A61K 3825

US Classification:

424 91

Abstract:

A diagnostic protocol and kit for evaluating pituitary growth hormone (GH) secretory capability as a means to identify the etiology of GH deficiency in children and adults is disclosed. The inventive protocol includes measuring GH secretion, provoked by independent, sequential administration of the xenobiotic GH releasing hexapeptide (GHRP-6) or any of its peptidyl or non-peptidyl synthetic analogues (GHRX) that release GH by the same cellular mechanism as GHRP-6 followed by the naturally occurring GH releasing hormone or its analogues (GHRH) to children and adults afflicted with disorders related to GH deficiency. After evaluating the effects of independent, sequential administration of the GH secretagogues upon changes in blood GH concentrations, the effect of the co-administered GH secretagogues on blood GH concentrations in the child or adult subject is then measured.