Inventors:
Jeffrey Bonanno - San Diego CA, US
J. Sauder - Carlsbad CA, US
Richard Fowler - San Diego CA, US
Richard Romero - San Diego CA, US
International Classification:
C12Q001/70, G06F019/00, G01N033/48, G01N033/50, C07K014/165, A61K039/12
US Classification:
424186100, 435005000, 530350000, 702019000
Abstract:
The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of SARS-CoV main protease and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of SARS M, SARS Mcrystals, and compounds and compositions that affect SARS Mactivity.