Inventors:
Richard David Semba - Baltimore MD, US
Luigi Ferruci - Baltimore MD, US
Edward G. Lakatta - Bethesda MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 47/40, G01N 33/566, A61K 47/16, A61K 47/42, A61P 3/10, A61K 47/14, A61K 47/02, A61K 47/04, A61P 13/12, A61P 9/10, G01N 33/53, A61K 47/38
US Classification:
514770, 435 792, 436501, 435 721, 514773, 514776, 514781, 514785, 514769
Abstract:
The present invention provides compositions and methods for detecting carboxymethyl-lysine (CML) and circulating receptor for advanced glycation end (RAGE) products, and methods for correlating CML and RAGE levels with age-related disease, hi particular, serum CML and/or circulating receptor for advanced glycation end (RAGE) products can be used as a clinical biomarker in diagnostics to identify people who are at a higher risk of developing adverse ageing-related outcomes.