Inventors:
Richard S. Surwit - Durham NC, US
Sheila A. Collins - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
A61K 31/5415, A61P 3/10, A61P 3/04
Abstract:
The present invention relates to a method of increasing the sensitivity of a hyperinsulinemic patient to the anti-obesity and antidiabetic effects of a β adrenergic receptor (βAR) agonist. The method comprises administering to the patient the βAR agonist and an agent that reduces plasma insulin levels and thereby increases the sensitivity of the patient to the effects of the βAR agonist.